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Article
Immunology
Heather Reese et al.
Summary: The study estimated that the number of laboratory-confirmed cases in the United States during the COVID-19 pandemic was lower than the actual number, and provided preliminary estimates to indicate the societal and healthcare burdens. These estimates can help inform resource allocation and mitigation planning.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
For Yue Tso et al.
Summary: The study found a higher prevalence of SARS-CoV-2 cross-reactive antibodies in pre-pandemic plasma samples from SSA compared to the USA, indicating potential cross-protection due to prior exposure to other coronaviruses in SSA. The detection of nucleocapsid proteins from HCoV-NL63 and HCoV-229E in most samples suggests these viruses as the likely sources of cross-reactive antibodies against SARS-CoV-2. The low incidence of SARS-CoV-2 infection and disease in SSA may be correlated with pre-pandemic serological cross-recognition of HCoVs, which are more prevalent in SSA than the USA.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Jennifer M. Dan et al.
Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.
Article
Multidisciplinary Sciences
Lewis F. Buss et al.
Summary: Research indicates that the attack rate of COVID-19 in Manaus, the capital of Amazonas state in northern Brazil, reached 66% in June 2020, rising to 76% by October, higher than the estimated attack rate of 29% in Sao Paulo, southeastern Brazil, during the same period.
Article
Multidisciplinary Sciences
Carleen Klumpp-Thomas et al.
Summary: The optimized ELISA-based serology protocol presented in this study helps define thresholds for IgG and IgM seropositivity with high specificities, minimal cross-reactivity, and flexible sample collection workflow, making it a valuable tool for standardized data generation on SARS-CoV-2 seropositivity, immunity, and infection.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Medicine, General & Internal
Ester C. Sabino et al.
Article
Biochemistry & Molecular Biology
Benjamin L. Rice et al.
Summary: The SARS-CoV-2 pandemic has shown low burdens in sub-Saharan Africa compared to other regions, potentially influenced by factors such as climate and population demographics. Caution is needed when interpreting analyses that aggregate data from low- and middle-income settings. Heterogeneity in connectivity across sub-Saharan Africa may contribute to variance in the pace of viral spread.
Article
Medicine, General & Internal
Raymond A. Harvey et al.
Summary: Understanding the impact of serum antibodies to SARS-CoV-2 on infection susceptibility is crucial for identifying at-risk populations and vaccine deployment. Results of the study suggest that individuals with positive antibody test results initially had a higher likelihood of positive NAAT results, but this likelihood decreased significantly over time, indicating that seropositivity may be associated with protection from infection, though the duration of this protection remains uncertain and may decrease over time.
JAMA INTERNAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Lloyd B. Mulenga et al.
Summary: The study revealed a significantly higher estimated number of SARS-CoV-2 infections compared to reported cases in six districts in Zambia. The high rtPCR-positive prevalence indicated community transmission, while the low ELISA-positive prevalence was likely influenced by early mitigation measures. It is important for Zambia to monitor the prevalence of SARS-CoV-2 and implement measures to reduce transmission.
LANCET GLOBAL HEALTH
(2021)
Letter
Public, Environmental & Occupational Health
Antoine Nkuba Ndaye et al.
LANCET GLOBAL HEALTH
(2021)
Editorial Material
Public, Environmental & Occupational Health
Jean Marie Milleliri et al.
Summary: The seroprevalence of SARS-CoV-2 infection was found to be high among gold miners and administrative staff in Ivory Coast, suggesting that the burden of infection in West Africa may have been underestimated.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Microbiology
Laura C. Steinhardt et al.
Summary: Accurate SARS-CoV-2 serological assays are crucial for COVID-19 surveillance, but cross-reactivity issues were found in areas with malaria endemicity. A simple urea wash can help alleviate this cross-reactivity problem.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Victoria Jane Hall et al.
Summary: The study aimed to determine the factors associated with vaccine coverage for two COVID-19 vaccines in the UK and to document the vaccine effectiveness of the BNT162b2 mRNA vaccine among healthcare workers. Results showed that the vaccine can prevent both symptomatic and asymptomatic infections in working-age adults, with a vaccine effectiveness of 70% after the first dose and 85% after the second dose.
Letter
Medicine, General & Internal
Salim S. Abdool Karim et al.
Summary: The emergence of SARS-CoV-2 variants, including B.1.1.7 (VOC-202012/01), 501Y.V2 (B.1.351), and P.1 (B.1.1.28.1), has raised concerns about worsening Covid-19 and potential escape from vaccine-induced immunity.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
Anges Yadouleton et al.
Summary: Commercially available ELISAs were used to test 68 samples from coronavirus disease cases and prepandemic controls from Benin, with less than 25% false-positive results noted among controls, likely due to unspecific immune responses elicited by acute malaria. It is important to carefully evaluate serologic tests to assess coronavirus disease spread and immunity in tropical regions.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Sophie Uyoga et al.
Summary: The prevalence of anti-SARS-CoV-2 immunoglobulin G among blood donors in Kenya from April to June 2020 was 4.3%, with the highest rates in urban counties like Mombasa, Nairobi, and Kisumu. This suggests that SARS-CoV-2 exposure is more widespread than case-based surveillance indicates.
Article
Public, Environmental & Occupational Health
M. Kariuki Njenga et al.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2020)
Article
Multidisciplinary Sciences
Wemboo Afiwa Halatoko et al.
Article
Veterinary Sciences
Zsolt Lang et al.
PREVENTIVE VETERINARY MEDICINE
(2014)
