期刊
EXPERT OPINION ON THERAPEUTIC TARGETS
卷 20, 期 11, 页码 1389-1392出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14728222.2016.1238899
关键词
Antidepressant; esketamine; hydroxynorketamine; ketamine; (R)-ketamine
资金
- Grants-in-Aid for Scientific Research [24116006] Funding Source: KAKEN
The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine is one of the most attractive antidepressants since this drug causes rapid-onset and sustained antidepressant effects in treatment resistant patients with depression. There are unanswered questions about how ketamine induces its rapid and sustained antidepressant actions. This key article suggests that (2R,6R)-HNK (hydroxynorketamine), a major metabolite of (R)-ketamine, shows antidepressant effects in rodent models of depression, indicating that the metabolism of (R)-ketamine to (2R,6R)-HNK is pivotal in its antidepressant action. Here these findings are put into context and their significance is discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据