☆ 4.4 Article

Lysophosphatidic acid receptor 6 regulated by miR-27a-3p attenuates tumor proliferation in breast cancer

CLINICAL & TRANSLATIONAL ONCOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Article Oncology

MAP17 contributes to non-small cell lung cancer progression via suppressing miR-27a-3p expression and p38 signaling pathway

Qian Liang et al.

Summary: MAP17 functions as an oncogene in NSCLC by suppressing the activation of the p38 pathway. Additionally, miR-27a-3p can inhibit the expression of MAP17, thereby suppressing the progression of NSCLC.

CANCER BIOLOGY & THERAPY (2021)

添加到收藏夹

Article Oncology

LncRNA PCAT7 promotes the malignant progression of breast cancer by regulating ErbB/PI3K/Akt pathway

Jiaoqun Zhou et al.

Summary: The high expression of PCAT7 in breast cancer promotes its occurrence and malignant progression by regulating the expression of downstream genes, providing a new molecular marker for cancer diagnosis.

FUTURE ONCOLOGY (2021)

添加到收藏夹

Review Chemistry, Medicinal

Lysophosphatidic acid (LPA) receptor modulators: Structural features and recent development

Bhagyalalitha Meduri et al.

Summary: Lysophosphatidic acid (LPA) and its receptors play crucial roles in cellular activities and are implicated in the pathogenesis of various diseases. Current research focuses on LPA receptors as new therapeutic targets for treating LPA-associated disorders.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells

Jiao Luo et al.

Summary: The study reveals that key alcohol-metabolizing enzymes are suppressed in patients with alcoholic hepatitis, while miR148a positively regulates ADH4 through a non-canonical mechanism, providing insights into a new regulatory pathway for ADH genes.

BIOCHEMICAL PHARMACOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Improving gene function predictions using independent transcriptional components

Carlos G. Urzua-Traslavina et al.

Summary: The study introduces a consensus independent component analysis and guilt-by-association approach to predict gene function, aiming to overcome the limitation in interpreting transcriptomic data. The results demonstrate that transcriptional components derived from independent component analysis enable more confident functionality predictions, improve predictions with the addition of new members to gene sets, and are less affected by gene multi-functionality. Predictions based on human or mouse transcriptomic data are publicly available for exploration on a web portal.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Review Oncology

Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression

Fabiana Luond et al.

Summary: Tumour heterogeneity, arising from intrinsic and extrinsic factors, has negative impacts on therapy response and prognosis. Cancer cell plasticity enables rapid adaptation to microenvironmental cues, playing a critical role in tumour progression and heterogeneity.

BRITISH JOURNAL OF CANCER (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Metastasis is altered through multiple processes regulated by the E2F1 transcription factor

Matthew R. Swiatnicki et al.

Summary: The E2F family of transcription factors plays a crucial role in cellular processes, including cell cycle regulation, angiogenesis, and metastasis. Alterations in the Rb/E2F pathway are associated with various cancers, such as breast cancer. Research on E2F1 ablation in breast cancer models revealed differences in genomic alterations related to tumor etiology, with potential disruptions in metastasis pathways.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Oncology

Atypical E2Fs either Counteract or Cooperate with RB during Tumorigenesis Depending on Tissue Context

Eva Moreno et al.

Summary: The study demonstrates a tissue-specific interaction between RB and atypical E2Fs in controlling tumorigenesis, showing enhanced tumorigenesis in the liver with combined loss of RB and atypical E2Fs, while inhibition of tumorigenesis in the pituitary gland. It suggests that atypical E2Fs and RB act cooperatively as tumor suppressors in hepatocytes, while atypical E2Fs may promote or inhibit tumorigenesis depending on tissue type and RB status, highlighting the context-dependent roles of these factors in maintaining genetic stability.

CANCERS (2021)

添加到收藏夹

Article Biology

OLIG2 regulates lncRNAs and its own expression during oligodendrocyte lineage formation

Haichao Wei et al.

Summary: The study integrated the genome-wide OLIG2 binding and epigenetic modification status of coding and non-coding genes during different stages of oligodendrocyte differentiation, revealing potential functions and regulation of lncRNAs by OLIG2. It discovered dynamic regulation of bivalent genes by OLIG2 during oligodendrocyte development and a novel self-regulation mechanism of OLIG2 through its own mRNA 3' UTR. These findings provide insights into the transcriptional and post-transcriptional mechanisms underlying oligodendrocyte development and contribute to understanding cell fate decisions during oligodendrocyte lineage formation.

BMC BIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

G protein gamma 7 suppresses progression of lung adenocarcinoma by inhibiting E2F transcription factor 1

Hongyu Zheng et al.

Summary: The G protein gamma 7 (GNG7) has been found to be aberrantly expressed in certain malignant tumors, with a study focusing on its antitumor role in lung adenocarcinoma (LUAD) cells. Down-regulation of GNG7 in LUAD tissues was found to correlate with patient survival. Functional experiments demonstrated that GNG7 acts as a tumor suppressor in LUAD cells by inhibiting E2F1 and suppressing cell proliferation, migration, and invasion.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

添加到收藏夹

Article Medicine, Research & Experimental

被撤回的出版物: Oncogenic miR-27a delivered by exosomes binds to SFRP1 and promotes angiogenesis in renal clear cell carcinoma (Retracted article. See vol. 30, pg. 346, 2022)

Yi Hou et al.

Summary: This study reveals that RCCC-derived miR-27a-loaded exosomes accelerate tumor angiogenesis in RCCC by inhibiting the expression of SFRP1.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

添加到收藏夹

Review Cell Biology

Lysophosphatidic Acid Receptor Antagonists and Cancer: The Current Trends, Clinical Implications, and Trials

Yu-Hsuan Lin et al.

Summary: Lysophosphatidic acid (LPA), a bioactive lipid mediator derived from membrane phospholipids, drives cellular effects by binding to LPA receptors. Selective antagonists targeting LPA receptors show therapeutic potential for various diseases, with ongoing preclinical trials for new LPA receptor antagonists. Targeting LPA receptors has potential clinical applications for patients with diverse diseases, including cancer.

CELLS (2021)

添加到收藏夹

Article Oncology

Association between sleep duration and breast cancer incidence: The multiethnic cohort

Maryssa Shigesato et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

添加到收藏夹

Review Oncology

Metastatic heterogeneity of breast cancer: Molecular mechanism and potential therapeutic targets

Yiran Liang et al.

SEMINARS IN CANCER BIOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A potential target for liver cancer management, lysophosphatidic acid receptor 6 (LPAR6), is transcriptionally up-regulated by the NCOA3 coactivator

Xuan Zheng et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

添加到收藏夹

Article Oncology

Impact of Breast Cancer Treatment on Employment: Results of a Multicenter Prospective Cohort Study (CANTO)

Agnes Dumas et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

添加到收藏夹

Article Genetics & Heredity

Novel lysophosphatidic acid receptor 6 antagonists inhibit hepatocellular carcinoma growth through affecting mitochondrial function

Davide Gnocchi et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Impact of GPCR Structures on Drug Discovery

Miles Congreve et al.

CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

The E2F family as potential biomarkers and therapeutic targets in colon cancer

Haibo Yao et al.

PEERJ (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A distinctive protein signature induced by lysophosphatidic acid receptor 6 (LPAR6) expression in hepatocellular carcinoma cells

Rosa Lippolis et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

添加到收藏夹

Article Oncology

MiR-27a-3p Targeting GSK3β Promotes Triple-Negative Breast Cancer Proliferation and Migration Through Wnt/β-Catenin Pathway

Ruizhen Wu et al.

CANCER MANAGEMENT AND RESEARCH (2020)

添加到收藏夹

Article Cell Biology

Endoplasmic reticulum stress-induced exosomal miR-27a-3p promotes immune escape in breast cancer via regulating PD-L1 expression in macrophages

Xiaoli Yao et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

MicroRNA-27a-3p Reverses Adriamycin Resistance by Targeting BTG2 and Activating PI3K/Akt Pathway in Breast Cancer Cells

Bei Zhu et al.

ONCOTARGETS AND THERAPY (2020)

添加到收藏夹

Review Oncology

Lysophosphatidic Acid Receptors: Biochemical and Clinical Implications in Different Diseases

Hongjiao Xiang et al.

JOURNAL OF CANCER (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Targeting the autotaxin - Lysophosphatidic acid receptor axis in cardiovascular diseases

Yang Zhao et al.

BIOCHEMICAL PHARMACOLOGY (2019)

添加到收藏夹

Article Genetics & Heredity

Lysophosphatidic Acid Receptor 6 (LPAR6) Expression and Prospective Signaling Pathway Analysis in Breast Cancer

Kai Tao et al.

MOLECULAR DIAGNOSIS & THERAPY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

MiR-466h-5p induces expression of myocardin with complementary promoter sequences

Ying Luo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Role of Non-coding RNAs in Oncology

Frank J. Slack et al.

CELL (2019)

添加到收藏夹

Article Oncology

Cell type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment

Silke Reinartz et al.

MOLECULAR ONCOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Patterns of diverse gene functions in genomic neighborhoods predict gene function and phenotype

Matej Mihelcic et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effects of LPA1 and LPA6 on the regulation of colony formation activity in colon cancer cells treated with anticancer drugs

Kaede Takahashi et al.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Integrated Human Evaluation of the Lysophosphatidic Acid Pathway as a Novel Therapeutic Target in Atherosclerosis

Silvia Aldi et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2018)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

SnapShot: Unconventional miRNA functions

Mihnea Paul Dragomir et al.

CELL (2018)

添加到收藏夹

Article Multidisciplinary Sciences

miRWalk: An online resource for prediction of microRNA binding sites

Carsten Sticht et al.

PLOS ONE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors

Nicholas G. Jendzjowsky et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Review Oncology

Targeting the Hippo Pathway for Breast Cancer Therapy

Liqing Wu et al.

CANCERS (2018)

添加到收藏夹

Article Oncology

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

Darshan S. Chandrashekar et al.

NEOPLASIA (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lysophosphatidic acid (LPA) signaling via LPA4 and LPA6 negatively regulates cell motile activities of colon cancer cells

Kaede Takahashi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells

Shuhei Ishii et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

添加到收藏夹

Article Oncology

Lysophosphatidic Acid Receptor LPAR6 Supports the Tumorigenicity of Hepatocellular Carcinoma

Antonio Mazzocca et al.

CANCER RESEARCH (2015)

添加到收藏夹

Article Cell Biology

Inactivation of a Gαs-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis

Ramiro Iglesias-Bartolome et al.

NATURE CELL BIOLOGY (2015)

添加到收藏夹

Article Biology

Predicting effective microRNA target sites in mammalian mRNAs

Vikram Agarwal et al.

ELIFE (2015)

添加到收藏夹

Article Developmental Biology

An essential role for LPA signalling in telencephalon development

Timothy J. Geach et al.

DEVELOPMENT (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma

Xuelian He et al.

NATURE MEDICINE (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Jianjiong Gao et al.

SCIENCE SIGNALING (2013)

添加到收藏夹

Article Oncology

bc-GenExMiner: an easy-to-use online platform for gene prognostic analyses in breast cancer

Pascal Jezequel et al.

BREAST CANCER RESEARCH AND TREATMENT (2012)

添加到收藏夹

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

添加到收藏夹

Article Genetics & Heredity

G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

Sandra M. Pasternack et al.

NATURE GENETICS (2008)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.