Ferroptosis: an iron-dependent cell death form linking metabolism, diseases, immune cell and targeted therapy

Compared with the traditional forms of cell death-apoptosis, necrosis and autophagy, ferroptosis is a novel form of iron-dependent programmed cell death forms which is different from the above traditional forms of cell death. Brent R Stockwell, a Professor of Columbia University, firstly proposed that this from of cell death was named ferroptosis in 2012. The main characteristics of ferroptosis is increasing iron loading and driving a lot of lipid peroxide generated and ultimately lead to cell death. In this paper, the mechanism of ferroptosis, relationship between ferroptosis and common diseases and immune state of body are reviewed, and the inhibitors and inducers related to ferroptosis that have been found are summarized to provide medicine exploration targeted of ferroptosis and reference for the research in the future.

Automated summary

Ferroptosis is a novel form of iron-dependent programmed cell death characterized by increased iron loading and lipid peroxidation leading to cell death. Research reviewed the mechanism of ferroptosis, its relationship with common diseases and immune status, and summarized inhibitors and inducers for targeted medicine exploration and future research.