4.5 Review

Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease

Zhentao Zhang et al.

NATURE COMMUNICATIONS (2015)

Article Clinical Neurology

Alzheimer disease and amyotrophic lateral sclerosis: an etiopathogenic connection

Xiaochuan Wang et al.

ACTA NEUROPATHOLOGICA (2014)

Article Chemistry, Medicinal

P3 SAR exploration of biphenyl carbamate based Legumain inhibitors

Catherine Higgins et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Article Neurosciences

Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A

Stephanie Chasseigneaux et al.

BMC NEUROSCIENCE (2014)

Editorial Material Biochemistry & Molecular Biology

Asparagine endopeptidase cleaves tau and promotes neurodegeneration

Hanna Rosenmann

NATURE MEDICINE (2014)

Article Biochemistry & Molecular Biology

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

Zhentao Zhang et al.

NATURE MEDICINE (2014)

Review Biochemistry & Molecular Biology

Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLDALS spectrum disorders

Jonathan Janssens et al.

HUMAN MOLECULAR GENETICS (2013)

Article Biochemistry & Molecular Biology

Activation of Asparaginyl Endopeptidase Leads to Tau Hyperphosphorylation in Alzheimer Disease

Gustavo Basurto-Islas et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Chemistry, Medicinal

Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain

Jiyoun Lee et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Review Endocrinology & Metabolism

Drug transport across the blood-brain barrier

William M. Pardridge

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)

Article Biochemical Research Methods

Asparaginyl endopeptidase cleaves TDP-43 in brain

Jeremy H. Herskowitz et al.

PROTEOMICS (2012)

Article Biochemistry & Molecular Biology

Asparagine endopeptidase is required for normal kidney physiology and homeostasis

Gail Miller et al.

FASEB JOURNAL (2011)

Article Biochemistry & Molecular Biology

Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2PP2A/SET

Lisette Arnaud et al.

FEBS LETTERS (2011)

Article Biochemistry & Molecular Biology

Development of Near-Infrared Fluorophore (NIRF)-Labeled Activity-Based Probes for in Vivo Imaging of Legumain

Jiyoun Lee et al.

ACS CHEMICAL BIOLOGY (2010)

Review Biochemistry & Molecular Biology

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

Clotilde Lagier-Tourenne et al.

HUMAN MOLECULAR GENETICS (2010)

Article Endocrinology & Metabolism

The asparaginyl endopeptidase legumain after experimental stroke

Taku Ishizaki et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2010)

Article Neurosciences

Reduced Levels of Amyloid-beta-Binding Proteins in Cerebrospinal Fluid from Alzheimer's Disease Patients

Sara F. Hansson et al.

JOURNAL OF ALZHEIMERS DISEASE (2009)

Article Biochemistry & Molecular Biology

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

Lionel M. Igaz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Multidisciplinary Sciences

Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome

Chi-Bun Chan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Cardiac & Cardiovascular Systems

Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis

Valerie Clerin et al.

ATHEROSCLEROSIS (2008)

Article Biochemistry & Molecular Biology

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Tetsuaki Arai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Article Biochemistry & Molecular Biology

Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine

Muhammad Omar Chohan et al.

FEBS LETTERS (2006)

Article Biochemistry & Molecular Biology

PIKE/nuclear PI 3-kinase signaling in preventing programmed cell death

KQ Ye

JOURNAL OF CELLULAR BIOCHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Asparagine deamidation perturbs antigen presentation on class II major histocompatibility complex molecules

CX Moss et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Cell Biology

PIKE GTPase: a novel mediator of phosphoinositide signaling

KQ Ye et al.

JOURNAL OF CELL SCIENCE (2004)

Article Biochemistry & Molecular Biology

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo

DTN Ni et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biotechnology & Applied Microbiology

Alzheimer's missing link?

[Anonymous]

MOLECULAR THERAPY (2003)

Article Biochemistry & Molecular Biology

Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

K Shirahama-Noda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Multidisciplinary Sciences

Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease

TC Gamblin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Prothymosin α is processed to thymosin α1 and thymosin α11 by a lysosomal asparaginyl endopeptidase

CS Sarandeses et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Inhibition of mammalian legumain by Michael acceptors and AzaAsn-halomethylketones

AJ Niestroj et al.

BIOLOGICAL CHEMISTRY (2002)

Review Biochemistry & Molecular Biology

Apolipoprotein E4 potentiates amyloid β peptide-induced lysosomal leakage and apoptosis in neuronal cells

ZS Ji et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Neurosciences

Lysosomal membrane damage in soluble Aβ-mediated cell death in Alzheimer's disease

K Ditaranto et al.

NEUROBIOLOGY OF DISEASE (2001)