Antibody response to first and second dose of BNT162b2 in a cohort of characterized healthcare workers

Article Biochemistry & Molecular Biology

Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Jordan R. Barrett et al.

Summary: The study demonstrates that a booster dose of ChAdOx1 nCoV-19 is safer and better tolerated than priming doses. The booster dose significantly enhances anti-spike neutralizing antibody titers and other functional antibody responses. These data support the two-dose vaccine regime currently being evaluated in phase 3 clinical trials.

NATURE MEDICINE (2021)

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Article Medical Laboratory Technology

Evaluation of the automated LIAISON (R) SARS-CoV-2 TrimericS IgG assay for the detection of circulating antibodies

Fabrizio Bonelli et al.

Summary: COVID-19 has led to an influx of tests from various manufacturers, with immunoassays playing a key role in epidemiological studies, longitudinal immunity understanding, and vaccine development. Evaluation of the LIAISON (R) SARS-CoV-2 TrimericS IgG assay demonstrated high sensitivity and specificity, making it suitable for use in high prevalence populations.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2021)

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Letter Medicine, General & Internal

Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals

Charlotte Manisty et al.

LANCET (2021)

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Letter Medicine, General & Internal

Antibody Responses in Seropositive Persons after a Single Dose of SARS-CoV-2 mRNA Vaccine

Florian Krammer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Letter Medicine, General & Internal

Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination

Venkata Viswanadh Edara et al.

Summary: This study investigates the neutralizing antibody response to 4 SARS-CoV-2 variants in individuals who have been infected or vaccinated.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Virology

Head-to-head comparison of two rapid high-throughput automated electrochemiluminescence immunoassays targeting total antibodies to the SARS-CoV-2 nucleoprotein and spike protein receptor binding domain

Mario Poljak et al.

Summary: The first head-to-head comparison of two rapid high-throughput automated electrochemiluminescence immunoassays targeting total anti-SARS-CoV-2 antibodies showed excellent agreement and high specificity, supporting the concurrent use of Elecsys-N and Elecsys-S in high-incidence settings for improved accuracy in detecting anti-SARS-CoV-2 antibodies.

JOURNAL OF CLINICAL VIROLOGY (2021)

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Article Medical Laboratory Technology