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Cardiac & Cardiovascular Systems
Matthew R. Fleming et al.
Summary: Novel targeted cancer therapies have brought revolution to oncology, but can lead to cardiovascular complications, particularly vascular side effects that are important considerations for cancer patients and survivors. Specifically, small-molecule kinase inhibitors like BTK inhibitors have shown significant impact on treatment and prognosis for B-cell malignancies, with cardiovascular side effects such as atrial fibrillation, increased bleeding risk, and hypertension posing challenges for clinicians. These complications can arise from on-target or off-target kinase inhibition, with emerging data suggesting off-target effects may provide insights into the development of arrhythmias like atrial fibrillation, offering potential insights into human cardiovascular biology.
CIRCULATION RESEARCH
(2021)
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Cardiac & Cardiovascular Systems
Richard A. Baylis et al.
Summary: Venous disease encompasses venous thromboembolic disease and chronic venous disease, with different pathophysiology caused by hemostasis imbalance and prolonged venous hypertension. Although environmental factors play a role, family history is also a significant risk factor.
CIRCULATION RESEARCH
(2021)
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Cardiac & Cardiovascular Systems
Eddie L. Hackler et al.
Summary: Peripheral artery disease disproportionately affects Black Americans and they are less likely to be diagnosed and treated promptly, leading to grim consequences. The review discusses the risk factors of the disease and how they differentially affect certain groups, providing a resource of available recommendations for clinical management.
CIRCULATION RESEARCH
(2021)
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Cardiac & Cardiovascular Systems
Derek Klarin et al.
Summary: Peripheral artery disease is a common and complex disease with both environmental and genetic determinants. Recent advances in genetic analysis have focused on identifying disease genes, rare variant and structural variant analysis, and the inclusion of individuals with diverse genetic ancestries in future studies.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Alyssa M. Flores et al.
Summary: Peripheral artery disease, an atherosclerotic disorder, can lead to poor patient outcomes if not diagnosed and managed properly. Machine learning and artificial intelligence technologies have great potential in healthcare, showing promise in disease detection, patient outcome prediction, and image interpretation. Despite being in the early stages of application to peripheral artery disease, these technologies offer tremendous prospects for enhancing care in the future.
CIRCULATION RESEARCH
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Cardiac & Cardiovascular Systems
Mary M. McDermott et al.
Summary: Aerobic exercise has positive effects on mitochondrial activity and muscle mass in older adults, but its impact on patients with peripheral artery disease remains unclear. Studies show that walking exercise may increase lower extremity ischemia in PAD patients, and more research is needed to clarify the underlying mechanisms.
CIRCULATION RESEARCH
(2021)
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Cardiac & Cardiovascular Systems
Joshua A. Beckman et al.
Summary: Effective revascularization in peripheral artery disease goes beyond just the procedure, requiring understanding of the urgency of revascularization based on the patient's presentation. Recent developments in tools and options such as open surgical bypass have improved outcomes in lower extremity revascularization, even though evidence to guide practice is limited.
CIRCULATION RESEARCH
(2021)
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Cardiac & Cardiovascular Systems
Esther S. H. Kim et al.
Summary: Multifocal fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection are both sex-biased diseases disproportionately affecting women over men in a 9:1 ratio. They share similarities in clinical presentations and genetic associations, particularly in terms of arterial abnormalities.
CIRCULATION RESEARCH
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Article
Cardiac & Cardiovascular Systems
Tom Alsaigh et al.
Summary: Peripheral arterial disease is a growing global problem, with a wide spectrum of clinical severity and significant economic impact. Despite advancements in therapies, there is a need for utilizing high-throughput discovery screens, novel translational models, and innovative trial designs. This review highlights recent advances in genomics and omics technologies, as well as new approaches to clinical studies for improving understanding and treatment of the disease.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Brian H. Annex et al.
Summary: PAD is a significant global cause of disability and mortality, primarily due to atherosclerotic obstructions in the large arteries to the leg(s). Despite advances in surgical and endovascular procedures, treatment outcomes may be suboptimal at times due to comorbid conditions or severe microvascular disease.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Aaron W. Aday et al.
Summary: PAD is increasingly recognized as a major cause of cardiovascular morbidity and mortality worldwide. The focus on PAD in recent years has led to new epidemiological insights and highlighted the importance of polyvascular disease in cardiovascular research and clinical practice. PAD may present similar or even greater risk compared to coronary artery disease or stroke.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Meaghan E. Colling et al.
Summary: The association between inflammation, infection, and venous thrombosis is crucial and can lead to pathological thrombosis. Cells like neutrophils, monocytes, and platelets play essential roles in host defense and thrombus formation. Understanding these mechanisms has advanced knowledge in human physiology and pathophysiology, offering new therapeutic targets for the treatment of thrombosis.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Stanley G. Rockson
Summary: In recent years, significant advancements have been made in the research and clinical approaches to lymphedema, particularly focusing on genetics, lymphatic imaging, and lymphatic surgery. New molecular insights and the relationships between lymphedema, obesity, and other comorbidities have been explored, providing valuable information for current and future responses to patients with lymphedema.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Marc P. Bonaca et al.
Summary: Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis with modifiable risk factors including smoking, dyslipidemia, and diabetes. Medical therapies can reduce the risk of major adverse cardiovascular events and major adverse limb events, and improve function. Diagnosis and treatment should consider the individual risk profile of the patient.
CIRCULATION RESEARCH
(2021)
