Fructose and metabolic diseases: too much to be good

Excessive consumption of fructose, the sweetest of all naturally occurring carbohydrates, has been linked to worldwide epidemics of metabolic diseases in humans, and it is considered an independent risk factor for cardiovascular diseases. We provide an overview about the features of fructose metabolism, as well as potential mechanisms by which excessive fructose intake is associated with the pathogenesis of metabolic diseases both in humans and rodents. To accomplish this aim, we focus on illuminating the cellular and molecular mechanisms of fructose metabolism as well as its signaling effects on metabolic and cardiovascular homeostasis in health and disease, highlighting the role of carbohydrate-responsive element-binding protein in regulating fructose metabolism.

Automated summary

Excessive consumption of fructose is linked to metabolic diseases epidemics and considered a risk factor for cardiovascular diseases. Research focuses on the cellular and molecular mechanisms of fructose metabolism, emphasizing the role of carbohydrate-responsive element-binding protein.