Chinese Medicine Regulates DNA Methylation to Treat Haematological Malignancies: A New Paradigm of State-Target Medicine

Aberrant regulation of DNA methylation plays a crucial causative role in haematological malignancies (HMs). Targeted therapy, aiming for DNA methylation, is an effective mainstay of modern medicine; however, many issues remain to be addressed. The progress of epigenetic studies and the proposed theory of state-target medicine have provided conditions to form a new treatment paradigm that combines the body state adjustment of CM with targeted therapy. We discussed the correlation between Chinese medicine (CM) syndromes/states and DNA methylation in this paper. Additionally, the latest research findings on the intervention and regulation of DNA methylation in HMs, including the core targets, therapy status, CM compounds and active components of the Chinese materia medica were concisely summarized to establish a theoretical foundation of state-target synchronous conditioning pattern of integrative medicine for HMs, simultaneously leading a new perspective in clinical diagnosis and therapy.

Automated summary

This article discusses the importance of DNA methylation in hematological malignancies and the new treatment paradigm combining Chinese medicine state adjustment with targeted therapy. By summarizing the latest research findings, a theoretical foundation for integrative medicine in treating hematological malignancies was established.