期刊
CHINESE JOURNAL OF CHEMISTRY
卷 39, 期 10, 页码 2852-2856出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.202100319
关键词
End group transformation; Block copolymers; Amino acid; Peptides; Peptoids
资金
- Joint Foundation of Shaanxi Province Natural Science Basic Research Program
- Shaanxi Coal Chemical Group Co., Ltd. [2019JLM-46]
- National Natural Science Foundation of China [21674091]
The study demonstrates that the triblock PAA-NHO-PTHF-ONH-PAA has high molecular weight and narrow dispersity, suitable for applications as polyether-poly(amino acid)s block copolymers. Due to the presence of oxygen amide groups in the backbone, these copolymers are cleavable under acidic conditions, showing potential in smart biomedicine and engineering.
Main observation and conclusion Block copolymers not only combine properties of different segments but also generate new application prospects. Poly(alpha-amino acid)-b-poly(tetrahydrofuran)-b-poly(alpha-amino acid) (PAA-PTHF-PAA) is one of the copolymers. In this contribution, di-hydroxyl-ended HO-PTHF-OH is transferred into di-oxyamino-ended H2NO-PTHF-ONH2 quantitatively, which is used as a macroinitiator to polymerize sarcosine N-thiocarboxyanhydride (Sar-NTA) and N-phenyoxycarbonyl N-epsilon-carbobenzyloxy-D-lysine (ZDL-NPC). Well-defined triblock PAA-NHO-PTHF-ONH-PAA is produced with high molecular weight (up to 25.3 kg/mol) and narrow dispersity. The amphiphilic PSar-NHO-PTHF-ONH-PSar (STS) self-assembles into micelles with uniform diameters of 30-40 nm according to DLS. Owing to oxygen amide groups inside the backbone of these copolymers, the polyether-poly(amino acid)s block copolymers are cleavable under an acidic environment and therefore have potential applications in smart biomedicine and engineering.
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