The Pd-catalyzed synthesis of difluoroethyl and difluorovinyl compounds with a chlorodifluoroethyl iodonium salt (CDFI)

Herein, we report a simple and efficient method for the direct installation of chlorodifluoroethyl group onto aromatic molecules of various aromatic amides with a new 2-chloro,2,2-difluoroethyl(mesityl)iodonium salt (CDFI). Moreover, the chlorodifluoroethyl compounds could be smoothly converted into difluorovinyl compounds in a one-pot or discrete procedure and regarded as a steady source of difluorovinyl compounds with HCl-mask. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

In this study, a simple and efficient method for directly introducing a chlorodifluoroethyl group into aromatic molecules of various aromatic amides is reported. A new 2-chloro,2,2-difluoroethyl(mesityl)iodonium salt (CDFI) is used in this method. Furthermore, the chlorodifluoroethyl compounds can be smoothly converted into difluorovinyl compounds and serve as a stable source of difluorovinyl compounds with HCl-mask.