期刊
CHINESE CHEMICAL LETTERS
卷 33, 期 2, 页码 587-596出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2021.08.020
关键词
Liposomes; Drug delivery; Biological drugs; Endocytosis; Toxicity
资金
- National Natural Science Foundation of China [81872823, 82073782]
- Shanghai Science and Technology Committee [19430741500]
- Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of Traditional Chinese Medicine, China [TCM-201905]
Biological drugs are limited in their application due to their inherent properties, but liposome-based drug delivery systems provide a promising solution to improve drug delivery.
Biological drugs are attracting tremendous attention in disease treatment. However, their application is significantly limited by their inherent properties, such as high hydrophilicity, poor membrane-permeability, low stability, and larger size. Liposome-based drug delivery systems are emerging as promising tools to improve their delivery, owing to their ability to reduce toxicity, improve bioavailability, and enhance the therapeutic efficacy of the drug by optimizing delivery to the specific target site. Here, we reviewed the types of liposomes and their applications as carriers for biological drugs to treat various diseases, emphasized the commercial products, and ultimately provided perspectives in this field. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
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