Triptycene-derived heterocalixarene: A new type of macrocycle-based stationary phases for gas chromatography

This work reports the investigation of a new triptycene-derived oxacalixarene (TDOC) as the stationary phase for gas chromatography (GC) with high-resolution performance for a wide range of analytes and isomers. The TDOC scaffold is composed of triptycene and 1,8-naphthyridine moieties, inherently differing from the conventional calixarenes in structures and properties. As a result, the TDOC column exhibited outstanding column efficiency of 5679 plates/m by n-dodecane at 120 degrees C. It showed advantageous performance for separations of the mixtures with various analytes and achieved high resolution of diverse isomers (skeletal, positional and cis-/trans-isomers) from apolar to polar nature. Moreover, the TDOC column exhibited high thermal stability up to 310 degrees C. To date, the TDOC-based materials have not been reported in chromatography. This work demonstrates the good potential of the triptycene-derived heterocalixarenes as a new class of stationary phases for chromatographic analyses. (C) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Automated summary

The new triptycene-derived oxacalixarene (TDOC) demonstrated excellent separation performance and high thermal stability as a stationary phase for gas chromatography, showing promise for separating various analytes and isomers.