Iron-catalyzed cyanoalkylation of difluoroenol silyl ethers with cyclobutanone oxime esters

An iron-catalyzed coupling reaction of difluoroenol silyl ethers and cyclobutanone oxime esters is described. This protocol provides a convenient access to various previously unknown and potentially useful gem-difluoromethylenated ketonitriles inmoderate to good yields. The transformations of resulting products to other fluorinecontaining products is also documented. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

An iron-catalyzed coupling reaction between difluoroenol silyl ethers and cyclobutanone oxime esters has been described, providing a convenient access to various gem-difluoromethylenated ketonitriles in moderate to good yields. The transformations of the resulting products to other fluorine-containing compounds are also documented.