Spatial trends and human health risks of organochlorinated pesticides from bovine milk; a case study from a developing country, Pakistan

Bovine milk is a nutritious food commodity extensively produced and consumed in Punjab, Pakistan. This study assesses the concentration profile of organochlorine pesticides (OCP; 18 compounds) in buffaloes and cow's milk in eight major districts of Punjab, Pakistan and the potential impacts of such exposure. The total OCPs in buffaloes and cow's milk samples ranged from 3.93 to 27.63 ng mL(-1) and 14.64-77.93 ng mL(-1) respectively. The overall pattern of mean OCPs concentration in buffaloes and cows milk showed that Hexachlorocyclohexanes (HCHs) are predominant followed by Heptachlors and Dichlorodiphenyltrichloroethane (DDTs). So far, the concentration profile depicted that Sigma HCHs, Sigma DDTs and Sigma Heptachlors did not exceed the maximum residual limits set for buffaloes and cow's milk. The spatial trends in terms of cluster analysis depicted significant variation (p > 0.05) among the districts in one cluster probably owing to local conditions. Furthermore, recently used DDTs were also identified at some of the selected districts. The risk assessment suggests that the estimated daily intake for each OCP was in accordance with the acceptable daily intake, thus single compound exposure does not pose a significant carcinogenic risk. However, the hazard ratios indicated that the values for Sigma DDTs posed risk in adults consuming cow's milk whereas children may face carcinogenic risk on the consumption of both buffalo and cow's milk. The risk may be altered where mixture is considered, furthermore, regarding carcinogenic risks a continuous monitoring based ecological analysis is recommended in the future. (C) 2021 Published by Elsevier Ltd.

Automated summary

The study assessed the concentration profile of organochlorine pesticides in buffalo and cow's milk in Punjab, Pakistan, as well as the potential impacts of such exposure. The results showed that Hexachlorocyclohexanes were the predominant OCPs, with recent use of DDTs detected in some districts. Risk assessment indicated potential risks for adults consuming cow's milk and carcinogenic risks for children consuming both buffalo and cow's milk. Further monitoring and ecological analysis are recommended for future research.