期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 27, 期 62, 页码 15528-15535出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202102701
关键词
Au(III)-hydride complex; DFT; photosubstitution; TD-DFT; two-photon absorption
资金
- project POR Calabria -FSE/FESR 2014-2020
- University of Calabria
- Calabria Region
Gold(III) complexes have been identified as new versatile and efficacious metal containing anticancer agents. This study focuses on a new series of cyclometalated Au(III)-hydride complexes proposed as photoactivatable anticancer prodrugs. The computational exploration of photophysical properties and reactivity of the first member of the series, named 1 a, has revealed interesting insights into its potential as a controlled detachment of the hydride ligand through photoactivation pathways.
Gold(III) complexes have recently emerged as new versatile and efficacious metal containing anticancer agents. In an attempt to reconcile the specific affinity of such complexes for target sulfur containing biomolecules with their capability to strongly bind thiol-containing compounds widely distributed in non-tumoral cells, a new series of cyclometalated Au(III)-hydride complexes has been proposed as photoactivatable anticancer prodrugs. Here, the computational exploration of the photophysical properties and reactivity in dark and under light irradiation of the first member of the series, named 1 a, is reported. Complex 1 a low hydricity in dark together with facile hydride substitution leading to H-2 elimination under excitation by visible light have been examined by means of DFT and TD-DFT computations. Both singlet and triplet excited states have been characterized, allowing the identification of the active species involved in photoactivation pathways leading to the controlled detachment of the hydride ligand. Also the viable two-photon activation at the ideal phototherapeutic window has been investigated.
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