期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 27, 期 43, 页码 11061-11064出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202101731
关键词
biaryls; chemoselectivity; Lewis bases; nucleophilic aromatic substitution; silicon
资金
- Deutsche Forschungsgemeinschaft [Oe 249/23-1]
- Alexander von Humboldt Foundation
- Projekt DEAL
This study presents a chemoselective C(sp(2))-C(sp(2)) coupling of electron-deficient fluorinated arenes and functionalized N-aryl-N'-silyldiazenes as masked aryl nucleophiles. The fluoride-promoted transformation involves in situ generation of aryl nucleophiles with sensitive functional groups followed by a stepwise SNAr reaction. These reactions proceed rapidly at room temperature, allowing for functionalization of both coupling partners and yielding highly fluorinated biaryls in good yields.
A chemoselective C(sp(2))-C(sp(2)) coupling of sufficiently electron-deficient fluorinated arenes and functionalized N-aryl-N'-silyldiazenes as masked aryl nucleophiles is reported. The fluoride-promoted transformation involves the in situ generation of the aryl nucleophile decorated with various sensitive functional groups followed by a stepwise nucleophilic aromatic substitution (SNAr). These reactions typically proceed at room temperature within minutes. This catalytic process allows for the functionalization of both coupling partners, furnishing highly fluorinated biaryls in good yields.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据