期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 27, 期 56, 页码 14057-14072出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202102308
关键词
boron; bioimaging; luminescence; nucleic acid; singlet oxygen
资金
- State of Bavaria Ministry of Science, Research, and the Arts
- Julius-Maximilians-Universitat Wurzburg
- Deutsche Forschungsgemeinschaft (DFG) [GRK2112]
- Croatian Science Foundation [IP-2018-01-5475]
- Deutscher Akademischer Austauschdienst (DAAD)
- Projekt DEAL
This study presents the synthesis, photophysical, and electrochemical properties of selectively mono-, bis- and tris-dimethylamino- and trimethylammonium-substituted bis-triarylborane bithiophene chromophores, as well as the water solubility and singlet oxygen sensitizing efficiency of cationic compounds. The research highlights the significant influence of the bridging unit on the properties of bis-triarylboranes, especially the cationic compounds, and investigates their interactions with DNA, RNA, and DNApore in buffered solutions. Additionally, the study explores the compounds' ability to enter and localize within organelles of human lung carcinoma and normal lung cells, showing that both the number and distribution of charges on the chromophore affect interactions and staining properties.
The synthesis, photophysical, and electrochemical properties of selectively mono-, bis- and tris-dimethylamino- and trimethylammonium-substituted bis-triarylborane bithiophene chromophores are presented along with the water solubility and singlet oxygen sensitizing efficiency of the cationic compounds Cat(1+), Cat(2+), Cat(i)(2+), and Cat(3+). Comparison with the mono-triarylboranes reveals the large influence of the bridging unit on the properties of the bis-triarylboranes, especially those of the cationic compounds. Based on these preliminary investigations, the interactions of Cat(1+), Cat(2+), Cat(i)(2+), and Cat(3+) with DNA, RNA, and DNApore were investigated in buffered solutions. The same compounds were investigated for their ability to enter and localize within organelles of human lung carcinoma (A549) and normal lung (WI38) cells showing that not only the number of charges but also their distribution over the chromophore influences interactions and staining properties.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据