Nickel-Catalyzed Thiolation of Aryl Nitriles

A nickel-catalyzed thiolation of aryl nitriles has been developed to access functionalized aryl thioethers. The ligand dcype (1,2-bis(dicyclohexylphosphino)ethane) as well as the base (KOBu)-Bu-t (potassium tert-butoxide) are essential to achieve this transformation. This scalable and practical process involves both a C-C bond activation and a C-S bond formation. Furthermore, this reaction shows a high functional-group tolerance and enables the late-stage functionalization of important molecules.

Automated summary

A nickel-catalyzed thiolation of aryl nitriles has been developed to access functionalized aryl thioethers, involving both C-C bond activation and C-S bond formation. This reaction shows high functional-group tolerance and enables late-stage functionalization of important molecules.