期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 27, 期 64, 页码 15908-15913出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202102854
关键词
acyloxyphosphonium; carboxylic acids; copper; difluoromethyl ketones; TMSCF3; trifluoromethyl ketones
资金
- Loker Hydrocarbon Research Institute
This method involves the synthesis of trifluoromethyl and difluoromethyl ketones from carboxylic acids using an acyloxyphosphonium ion as the active electrophile, showing tolerance to various functional groups and applicability to late-stage functionalization of pharmaceutical compounds.
A simple and straightforward approach to the synthesis of trifluoromethyl and difluoromethyl ketones from widely available carboxylic acids is disclosed. The transformation utilizes an acyloxyphosphonium ion as the active electrophile, conveniently generated in situ from the carboxylic acid substrate by using commodity chemicals. The utility of the reaction system is exemplified by its chemoselectivity, with tolerance to a variety of important functional groups. The late-stage functionalization of carboxylic acid active pharmaceutical ingredients and pharmaceutically relevant compounds is also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据