期刊
CHEMISTRY OF NATURAL COMPOUNDS
卷 57, 期 4, 页码 706-711出版社
SPRINGER
DOI: 10.1007/s10600-021-03454-3
关键词
betulin; 3-oxo-28-hydroxylup-20(29)-ene; dicarboxylic acids; [2+1]-reaction; alpha, omega-diketodiesters; synthesis
资金
- RFBR [20-33-90200]
A new synthesis method was developed to produce 3-oxo-28-hydroxylup-20(29)-ene from the natural triterpenoid betulin. Alpha, omega-diketodiesters were successfully prepared for the first time by different methods, with the highest yields obtained under Steglich reaction conditions. One of the synthesized alpha, omega-diketodiesters exhibited moderate in vitro activity against A-549 lung carcinoma cells.
A new synthesis of 3-oxo-28-hydroxylup-20(29)-ene from the available natural triterpenoid betulin was developed. alpha,omega-Diketodiesters were prepared for the first time by different methods from 3-oxo-28-hydmxylup-20(29)-ene and a series of natural dicarboxylic acids. Steglich reaction conditions gave the highest yields. One of the synthesized alpha, omega-diketodiesters was moderately active in vitro against A-549 lung carcinoma.
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