4.3 Article

Copper-mediated Regioselective C-H Cyanation of Phenols with Assistance of Bipyridine-type Bidentate Auxiliary

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Article Chemistry, Organic

Bipyridine-Type Bidentate Auxiliary-Enabled Copper-Mediated C-H/C-H Biaryl Coupling of Phenols and 1,3-Azoles

Rikuo Kajiwara et al.

Summary: A copper-mediated dehydrogenative C-H/C-H biaryl coupling of phenols and 1,3-azoles was developed, with the key to success being the introduction of a bipyridine-type bidentate auxiliary. The reaction proceeds smoothly in the presence of copper salt alone to form the corresponding phenol-azole heterobiaryls.

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