期刊
CHEMISTRY AND PHYSICS OF LIPIDS
卷 239, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2021.105103
关键词
PAF-AH II; Substrate specificity; Activity assays; Inhibitors; Biological activities
资金
- National Natural Science Foundation of China [81973458]
- Shanghai Science and Technology Innovation action plan [18401931100]
- program of Shanghai E-research Institute of Bioactive Constituents in Traditional Chinese Medicine
Intracellular platelet activating-factor acetylhydrolase type II (PAF-AH II) is a monomeric enzyme with broad substrate specificity and various functions such as protection against oxidative stress, transacetylase activity, and producing lipid mediators. It has been proven to be involved in several diseases and has drawn attention from researchers.
Intracellular platelet activating-factor acetylhydrolase type II (PAF-AH II) is a 40-kDa monomeric enzyme. It was originally identified as an enzyme that hydrolyzes the acetyl group of PAF (1-O-alkyl-2-acetyl-sn-glycero-3phosphocholine). As a member of phospholipase A2 super family, PAF-AH II has broad substrate specificity. It can hydrolyze phospholipids with relatively short-length or oxidatively modified sn-2 chains which endows it with various functions such as protection against oxidative stress, transacetylase activity and producing lipid mediators. PAF-AH II has been proven to be involved in several diseases such as allergic diseases, oxidative stress-induced injury and ischemia injury, thus it has drawn more attention from researchers. In this paper, we outline an entire summary of PAF-AH II, including its structure, substrate specificity, activity assay, inhibitors and biological activities.
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