The disturbance of lipid metabolism is correlated with neuropsychiatric symptoms in patients with Parkinson's disease

Objective: We aimed to identify the detailed relationships between serum lipid levels and neuropsychiatric symptoms in patients with Parkinson's disease (PD). Methods: Consecutive PD patients and healthy controls were recruited and demographic data were collected. The disease stages of PD patients were assessed using Hoehn-Yahr scale while neuropsychiatric symptoms were determined using Hamilton depression rating scale (HAMD), Hamilton anxiety rating scale (HAMA), and minimental state examination scale. Fast serum samples were obtained and the serum levels of lipids were identified. Linear regression analyses and correlation analyses were performed to explore the relationships between serum lipid levels and neuropsychiatric symptoms. Results: The serum levels of triglyceride had significantly decreased while the levels of HDL-c and lipoprotein a had increased in PD patients. Linear regression analyses confirmed that the levels of triglyceride were mainly correlated with age and HAMA score, the levels of HDL-c were correlated with disease duration and gender, and the levels of lipoprotein a were correlated with HAMD score. Correlation analyses further confirmed that the levels of triglyceride were negatively correlated with HAMA score when the levels of lipoprotein a were negatively correlated with HAMD score. Conclusions: Lipid metabolism is significantly correlated with neuropsychiatric disorders in PD patients.

Automated summary

This study identified detailed relationships between serum lipid levels and neuropsychiatric symptoms in Parkinson's disease (PD) patients. It was found that triglyceride levels decreased, while HDL-c and lipoprotein a levels increased in PD patients. Triglyceride levels were negatively correlated with HAMA score, while lipoprotein a levels were negatively correlated with HAMD score.