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Mei Lu et al.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)
Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs
Owen S. Fenton et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)
PEGylated DC-Chol/DOPE cationic liposomes containing KSP siRNA as a systemic siRNA delivery Carrier for ovarian cancer therapy
Jinju Lee et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
Immune lipoprotein nanostructures inspired relay drug delivery for amplifying antitumor efficiency
Yue Han et al.
BIOMATERIALS (2018)
Optimization of siRNA delivery to target sites: issues and future directions
Ikramy A. Khalil et al.
EXPERT OPINION ON DRUG DELIVERY (2018)
Nanoparticles Based on Poly (β-Amino Ester) and HPV16-Targeting CRISPR/shRNA as Potential Drugs for HPV16-Related Cervical Malignancy
Da Zhu et al.
MOLECULAR THERAPY (2018)
Biomedical applications of mRNA nanomedicine
Qingqing Xiong et al.
NANO RESEARCH (2018)
Alnylam launches era of RNAi drugs
Ken Garber
NATURE BIOTECHNOLOGY (2018)
FDA approves landmark RNAi drug
Asher Mullard
NATURE REVIEWS DRUG DISCOVERY (2018)
mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice
Ole A. W. Haabeth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Sugar Functionalized Synergistic Dendrimers for Biocompatible Delivery of Nucleic Acid Therapeutics
Shuqin Han et al.
POLYMERS (2018)
RNA Interference as a Prospective Tool for the Control of Human Viral Infections
Alesia Levanova et al.
FRONTIERS IN MICROBIOLOGY (2018)
Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA
Mohammad Ariful Islam et al.
NATURE BIOMEDICAL ENGINEERING (2018)
Synthetic materials at the forefront of gene delivery
Irene Lostale-Seijo et al.
NATURE REVIEWS CHEMISTRY (2018)
Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I
Qiang Cheng et al.
ADVANCED MATERIALS (2018)
Exosomes: natural nanoparticles as bio shuttles for RNAi delivery
Saber Ghazizadeh Darband et al.
JOURNAL OF CONTROLLED RELEASE (2018)
Light-Controlled Lipid Interaction and Membrane Organization in Photolipid Bilayer Vesicles
Patrick Urban et al.
LANGMUIR (2018)
A Review on Electroporation-Based Intracellular Delivery
Junfeng Shi et al.
MOLECULES (2018)
High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing
Cory D. Sago et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo
Tia DiTommaso et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Targeted delivery of antisense oligonucleotides to pancreatic β-cells
C. Ammala et al.
SCIENCE ADVANCES (2018)
Stable and efficient generation of poly(β-amino ester)s for RNAi delivery
P. Dosta et al.
MOLECULAR SYSTEMS DESIGN & ENGINEERING (2018)
The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds
Hiroki Tanaka et al.
HELIYON (2018)
Amphiphilic small peptides for delivery of plasmid DNAs and siRNAs
Eun-Kyoung Bang et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2018)
Current knowledge on exosome biogenesis and release
Nina Pettersen Hessvik et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2018)
Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA
Jason B. Miller et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization
Rebecca L. Ball et al.
INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)
Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy
Matthias A. Oberli et al.
NANO LETTERS (2017)
Lipid Nanoparticles Loaded with an Antisense Oligonucleotide Gapmer Against Bcl-2 for Treatment of Lung Cancer
Xinwei Cheng et al.
PHARMACEUTICAL RESEARCH (2017)
Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes
Shuaijian Ni et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Biodegradable lipid nanoparticles induce a prolonged RNA interference-mediated protein knockdown and show rapid hepatic clearance in mice and nonhuman primates
Yuta Suzuki et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)
Exosomes: Nanoparticulate tools for RNA interference and drug delivery
Fahimeh Shahabipour et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2017)
pH-labile PEGylation of siRNA-loaded lipid nanoparticle improves active targeting and gene silencing activity in hepatocytes
Kazuki Hashiba et al.
JOURNAL OF CONTROLLED RELEASE (2017)
Retinal gene delivery enhancement by lycopene incorporation into cationic niosomes based on DOTMA and polysorbate 60
Mohamed Mashal et al.
JOURNAL OF CONTROLLED RELEASE (2017)
The Delivery of Small Interfering RNA to Hepatic Stellate Cells Using a Lipid Nanoparticle Composed of a Vitamin A-Scaffold Lipid-Like Material
Naoyuki Toriyabe et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
PEGylation of the GALA Peptide Enhances the Lung-Targeting Activity of Nanocarriers That Contain Encapsulated siRNA
Sarochin Santiwarangkool et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
Systemic Delivery of Complexes of Melanoma RNA with Mannosylated Liposomes Activates Highly Efficient Murine Melanoma-Specific Cytotoxic T Cells In Vivo
O. V. Markov et al.
MOLECULAR BIOLOGY (2017)
Efficient Targeting and Activation of Antigen Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques
Frank Liang et al.
MOLECULAR THERAPY (2017)
Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer
Jon Voutila et al.
MOLECULAR THERAPY (2017)
Lipid Nanoparticle Systems for Enabling Gene Therapies
Pieter R. Cullis et al.
MOLECULAR THERAPY (2017)
Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses
Kapil Bahl et al.
MOLECULAR THERAPY (2017)
Adamantane in Drug Delivery Systems and Surface Recognition
Adela Stimac et al.
MOLECULES (2017)
Cell membrane-derived nanoparticles: emerging clinical opportunities for targeted drug delivery
Svetlana T. Yurkin et al.
NANOMEDICINE (2017)
Cationic switchable lipids: pH-triggered molecular switch for siRNA delivery
W. Viricel et al.
NANOSCALE (2017)
Microfluidic self-assembly of folate-targeted monomolecular siRNA-lipid nanoparticles
R. Krzyszton et al.
NANOSCALE (2017)
Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides
Naoki Iwamoto et al.
NATURE BIOTECHNOLOGY (2017)
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
Hao Yin et al.
NATURE BIOTECHNOLOGY (2017)
Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol
Kausik K. Ray et al.
NEW ENGLAND JOURNAL OF MEDICINE (2017)
Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics
James E. Dahlman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals
Colin J. McKinlay et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Systemic delivery of factor IX messenger RNA for protein replacement therapy
Suvasini Ramaswamy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Immunogenicity and protective efficacy induced by self-amplifying mRNA vaccines encoding bacterial antigens
Giulietta Maruggi et al.
VACCINE (2017)
Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles
Laura I. Selby et al.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2017)
Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis
Jia-Lin Huang et al.
NATURE COMMUNICATIONS (2017)
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
Norbert Pardi et al.
NATURE COMMUNICATIONS (2017)
Molecular Mechanisms of Antisense Oligonucleotides
Stanley T. Crooke
NUCLEIC ACID THERAPEUTICS (2017)
Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo
Xi Zhu et al.
THERANOSTICS (2017)
RNA in extracellular vesicles
Kyoung Mi Kim et al.
WILEY INTERDISCIPLINARY REVIEWS-RNA (2017)
Cationic Nanoliposomes Meet mRNA: Efficient Delivery of Modified mRNA Using Hemocompatible and Stable Vectors for Therapeutic Applications
Tatjana Michel et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2017)
Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing
Yu Cao et al.
FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING (2017)
High-throughput nuclear delivery and rapid expression of DNA via mechanical and electrical cell-membrane disruption
Xiaoyun Ding et al.
NATURE BIOMEDICAL ENGINEERING (2017)
Understanding the formation mechanism of lipid nanoparticles in microfluidic devices with chaotic micromixers
Masatoshi Maeki et al.
PLOS ONE (2017)
Tumor-targeted delivery of siRNA using fatty acyl-CGKRK peptide conjugates
Meenakshi Sharma et al.
SCIENTIFIC REPORTS (2017)
Cleavable PEGylation: a strategy for overcoming the PEG dilemma in efficient drug delivery
Yan Fang et al.
DRUG DELIVERY (2017)
Microfluidic-Enabled Intracellular Delivery of Membrane Impermeable Inhibitors to Study Target Engagement in Human Primary Cells
Jing Li et al.
ACS CHEMICAL BIOLOGY (2017)
Phase-Separated Liposomes Enhance the Efficiency of Macromolecular Delivery to the Cellular Cytoplasm
Zachary I. Imam et al.
CELLULAR AND MOLECULAR BIOENGINEERING (2017)
Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes
Owen S. Fenton et al.
ADVANCED MATERIALS (2017)
Interfacially Engineered Pyridinium Pseudogemini Surfactants as Versatile and Efficient Supramolecular Delivery Systems for DNA, siRNA, and mRNA
Uttam Satyal et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Functionalized bioengineered spider silk spheres improve nuclease resistance and activity of oligonucleotide therapeutics providing a strategy for cancer treatment
Anna Karolina Kozlowska et al.
ACTA BIOMATERIALIA (2017)
Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects
Sven Kruspe et al.
BIOMEDICINES (2017)
Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth
James V. Michael et al.
BLOOD (2017)
Biodegradable Amino-Ester Nanomaterials for Cas9 mRNA Delivery in Vitro and in Vivo
Xinfu Zhang et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease
Justin M. Richner et al.
CELL (2017)
Lipopolyplex potentiates anti-tumor immunity of mRNA-based vaccination
Stefano Persano et al.
BIOMATERIALS (2017)
Modified mRNA Vaccines Protect against Zika Virus Infection
Justin M. Richner et al.
CELL (2017)
Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors
Yunfeng Yan et al.
BIOMATERIALS (2017)
Advancement of the Emerging Field of RNA Nanotechnology
Daniel Jasinski et al.
ACS NANO (2017)
Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin
Michela Brazzoli et al.
JOURNAL OF VIROLOGY (2016)
Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy
Chengzu Long et al.
SCIENCE (2016)
Role of Cell Membrane Vector Interactions in Successful Gene Delivery
Sriram Vaidyanathan et al.
ACCOUNTS OF CHEMICAL RESEARCH (2016)
Design of Highly Potent Lipid-Functionalized Peptidomimetics for Efficient in Vivo siRNA Delivery
Hai Xiao et al.
ACS APPLIED MATERIALS & INTERFACES (2016)
Efficient Cellular Knockdown Mediated by siRNA Nanovectors of Gemini Cationic Lipids Having Delocalizable Headgroups and Oligo-Oxyethylene Spacers
Maria Martinez-Negro et al.
ACS APPLIED MATERIALS & INTERFACES (2016)
High-Density Lipoproteins: Nature's Multifunctional Nanoparticles
Rui Kuai et al.
ACS NANO (2016)
The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery
Xinwei Cheng et al.
ADVANCED DRUG DELIVERY REVIEWS (2016)
Properties of Native High-Density Lipoproteins Inspire Synthesis of Actively Targeted In Vivo siRNA Delivery Vehicles
Kaylin M. McMahon et al.
ADVANCED FUNCTIONAL MATERIALS (2016)
PGMA-Based Star-Like Polycations with Plentiful Hydroxyl Groups Act as Highly Efficient miRNA Delivery Nanovectors for Effective Applications in Heart Diseases
Rui-Quan Li et al.
ADVANCED MATERIALS (2016)
Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery
Owen S. Fenton et al.
ADVANCED MATERIALS (2016)
Coordinative Amphiphiles as Tunable siRNA Transporters
Jin Bum Kim et al.
BIOCONJUGATE CHEMISTRY (2016)
Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype
Mariana Conceicao et al.
BIOMATERIALS (2016)
Comparative Study of the Condensing Effects of Ergosterol and Cholesterol
Wei-Chin Hung et al.
BIOPHYSICAL JOURNAL (2016)
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go
Mercedes Tkach et al.
CELL (2016)
Lipidoid Tail Structure Strongly Influences siRNA Delivery Activity
Christopher M. Knapp et al.
CELLULAR AND MOLECULAR BIOENGINEERING (2016)
Structural studies of the formation of lipoplexes between siRNA and selected bis-imidazolium gemini surfactants
W. Andrzejewska et al.
COLLOIDS AND SURFACES B-BIOINTERFACES (2016)
Synthesis and evaluation of novel lipopeptide as a vehicle for efficient gene delivery and gene silencing
O. O. Koloskova et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2016)
Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system
F. DeRosa et al.
GENE THERAPY (2016)
Anti-EphA10 antibody-conjugated pH-sensitive liposomes for specific intracellular delivery of siRNA
Xinlong Zang et al.
INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)
Nanomedicine engulfed by macrophages for targeted tumor therapy
Siwen Li et al.
INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)
Efficient delivery of Notch1 siRNA to SKOV3 cells by cationic cholesterol derivative-based liposome
Yun-Chun Zhao et al.
INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)
Structure, activity and uptake mechanism of siRNA-lipid nanoparticles with an asymmetric ionizable lipid
Yuta Suzuki et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)
The role of helper lipids in the intracellular disposition and transfection efficiency of niosome formulations for gene delivery to retinal pigment epithelial cells
Edilberto Ojeda et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)
Effect of particle size on their accumulation in an inflammatory lesion in a dextran sulfate sodium (DSS)-induced colitis model
Ayaka Watanabe et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)
Extracellular vesicles: masters of intercellular communication and potential clinical interventions
Jonathan M. Pitt et al.
JOURNAL OF CLINICAL INVESTIGATION (2016)
A phase Ib/IIa study of combination therapy with gemcitabine and Atu027 in patients with locally advanced or metastatic pancreatic adenocarcinoma.
Beate Schultheis et al.
JOURNAL OF CLINICAL ONCOLOGY (2016)
A lipid nanoparticle for the efficient delivery of siRNA to dendritic cells
Shota Warashina et al.
JOURNAL OF CONTROLLED RELEASE (2016)
Delivery of siRNA targeting tumor metabolism using non-covalent PEGylated chitosan nanoparticles: Identification of an optimal combination of ligand structure, linker and grafting method
Cyril Corbet et al.
JOURNAL OF CONTROLLED RELEASE (2016)
Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation
Zhaogang Yang et al.
JOURNAL OF CONTROLLED RELEASE (2016)
Materials for non-viral intracellular delivery of messenger RNA therapeutics
Kevin J. Kauffman et al.
JOURNAL OF CONTROLLED RELEASE (2016)
Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA
Sam Chen et al.
JOURNAL OF CONTROLLED RELEASE (2016)
The role of disulfide-bridge on the activities of H-shape gemini-like cationic lipid based siRNA delivery
Xiao-Fei Ma et al.
JOURNAL OF CONTROLLED RELEASE (2016)
Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection
Naoki Yamamoto et al.
JOURNAL OF HEPATOLOGY (2016)
Design of Ionizable Lipids To Overcome the Limiting Step of Endosomal Escape: Application in the Intracellular Delivery of mRNA, DNA, and siRNA
Damien Habrant et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Effects of HMGA2 siRNA and doxorubicin dual delivery by chitosan nanoparticles on cytotoxicity and gene expression of HT-29 colorectal cancer cell line
Homayoon Siahmansouri et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2016)
Novel Targeted Therapy for Precursor B-Cell Acute Lymphoblastic Leukemia: Anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugate
Noriko Satake et al.
MOLECULAR MEDICINE (2016)
Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System
Xiaona Jing et al.
MOLECULAR PHARMACEUTICS (2016)
Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression
Irene C. Turnbull et al.
MOLECULAR THERAPY (2016)
Relationship Between the Physicochemical Properties of Lipid Nanoparticles and the Quality of siRNA Delivery to Liver Cells
Yusuke Sato et al.
MOLECULAR THERAPY (2016)
Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo
Yizhou Dong et al.
NANO LETTERS (2016)
Biodistribution and pharmacokinetics of Mad2 siRNA-loaded EGFR-targeted chitosan nanoparticles in cisplatin sensitive and resistant lung cancer models
Ana Vanessa Nascimento et al.
NANOMEDICINE (2016)
Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines
Thomas Demoulins et al.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
Lena M. Kranz et al.
NATURE (2016)
A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice
Yang Yang et al.
NATURE BIOTECHNOLOGY (2016)
Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose
Jasdave S. Chahal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles
Ming Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells
Yunfeng Yan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model
Kejin Zhou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Looking Beyond Structure: Membrane Phospholipids of Skeletal Muscle Mitochondria
Timothy D. Heden et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2016)
Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich's ataxia
Joseph F. Nabhan et al.
SCIENTIFIC REPORTS (2016)
Mono-arginine Cholesterol-based Small Lipid Nanoparticles as a Systemic siRNA Delivery Platform for Effective Cancer Therapy
Jinju Lee et al.
THERANOSTICS (2016)
Targeted Dual pH-Sensitive Lipid ECO/siRNA Self-Assembly Nanoparticles Facilitate In Vivo Cytosolic sieIF4E Delivery and Overcome Paclitaxel Resistance in Breast Cancer Therapy
Maneesh Gujrati et al.
Advanced Healthcare Materials (2016)
Exosome-mediated small RNA delivery for gene therapy
Yu Zhou et al.
WILEY INTERDISCIPLINARY REVIEWS-RNA (2016)
Enhanced siRNA delivery of a cyclododecylated dendrimer compared to its linear derivative
Wanwan Shen et al.
JOURNAL OF MATERIALS CHEMISTRY B (2016)
Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges
Dinh Ha et al.
ACTA PHARMACEUTICA SINICA B (2016)
Effects of local structural transformation of lipid-like compounds on delivery of messenger RNA
Bin Li et al.
SCIENTIFIC REPORTS (2016)
Laser-assisted photoporation: fundamentals, technological advances and applications
Ranhua Xiong et al.
ADVANCES IN PHYSICS-X (2016)
siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes
Shigeo Matsuda et al.
ACS CHEMICAL BIOLOGY (2015)
Stealth monoolein-based nanocarriers for delivery of siRNA to cancer cells
Ana C. N. Oliveira et al.
ACTA BIOMATERIALIA (2015)
In vivo delivery of miRNAs for cancer therapy: Challenges and strategies
Yunching Chen et al.
ADVANCED DRUG DELIVERY REVIEWS (2015)
Preclinical and clinical development of siRNA-based therapeutics
Gulnihal Ozcan et al.
ADVANCED DRUG DELIVERY REVIEWS (2015)
Antisense oligonucleotides in therapy for neurodegenerative disorders
Melvin M. Evers et al.
ADVANCED DRUG DELIVERY REVIEWS (2015)
Switchable Lipids: Conformational Change for Fast pH-Triggered Cytoplasmic Delivery
Warren Viricel et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Biodegradable Stearylated Peptide with Internal Disulfide Bonds for Efficient Delivery of siRNA In Vitro and In Vivo
Zongguang Tai et al.
BIOMACROMOLECULES (2015)
Silencing β3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT and Metastasis of Triple-Negative Breast Cancer
Jenny G. Parvani et al.
CANCER RESEARCH (2015)
pH-Cleavable Nucleoside Lipids: A New Paradigm for Controlling the Stability of Lipid-Based Delivery Systems
Khalid Oumzil et al.
CHEMMEDCHEM (2015)
Lipid-Based Nanocarriers for RNA Delivery
Hui Yi Xue et al.
CURRENT PHARMACEUTICAL DESIGN (2015)
Fatty acid modified octa-arginine for delivery of siRNA
Yuhuan Li et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)
Multicomponent mannose-containing liposomes efficiently deliver RNA in murine immature dendritic cells and provide productive anti-tumour response in murine melanoma model
Oleg V. Markov et al.
JOURNAL OF CONTROLLED RELEASE (2015)
A neutral lipid envelope-type nanoparticle composed of a pH-activated and vitamin E-scaffold lipid-like material as a platform for a gene carrier targeting renal cell carcinoma
Hidetaka Akita et al.
JOURNAL OF CONTROLLED RELEASE (2015)
siRNA-lipid nanoparticles with long-term storage stability facilitate potent gene-silencing in vivo
Y. Suzuki et al.
JOURNAL OF CONTROLLED RELEASE (2015)
siRNA delivery to lung-metastasized tumor by systemic injection with cationic liposomes
Yoshiyuki Hattori et al.
JOURNAL OF LIPOSOME RESEARCH (2015)
Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery
Jing Hao et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
Lipid-PEG Conjugates Sterically Stabilize and Reduce the Toxicity of Phytantriol-Based Lyotropic Liquid Crystalline Nanoparticles
Jiali Zhai et al.
LANGMUIR (2015)
mRNA: Fulfilling the Promise of Gene Therapy
Drew Weissman et al.
MOLECULAR THERAPY (2015)
Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature
Omar F. Khan et al.
NANO LETTERS (2015)
An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo
Bin Li et al.
NANO LETTERS (2015)
Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
Kevin J. Kauffman et al.
NANO LETTERS (2015)
Combinatorial library strategies for synthesis of cationic lipid-like nanoparticles and their potential medical applications
Sarah Altinoglu et al.
NANOMEDICINE (2015)
Nanoparticle biointerfacing by platelet membrane cloaking
Che-Ming J. Hu et al.
NATURE (2015)
Therapeutic genome editing: prospects and challenges
David Benjamin Turitz Cox et al.
NATURE MEDICINE (2015)
Clinical experiences with systemically administered siRNA-based therapeutics in cancer
Jonathan E. Zuckerman et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
Knocking down disease: a progress report on siRNA therapeutics
Anders Wittrup et al.
NATURE REVIEWS GENETICS (2015)
Programmable materials and the nature of the DNA bond
Matthew R. Jones et al.
SCIENCE (2015)
Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery
Dali Wang et al.
CHEMICAL SCIENCE (2015)
Turning Squalene into Cationic Lipid Allows a Delivery of siRNA in Cultured Cells
Jean-Remi Bertrand et al.
NUCLEIC ACID THERAPEUTICS (2015)
Cell or Cell Membrane-Based Drug Delivery Systems
Songwei Tan et al.
THERANOSTICS (2015)
Synthesis, Physicochemical Characterization, and Interaction with DNA of Long-Alkyl-Chain Gemini Pyridinium Surfactants
Nadia Barbero et al.
CHEMPLUSCHEM (2015)
Recombinant messenger RNA technology and its application in cancer immunotherapy, transcript replacement therapies, pluripotent stem cell induction, and beyond
Britta Vallazza et al.
WILEY INTERDISCIPLINARY REVIEWS-RNA (2015)
Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol
Tomoko Nishina et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2015)
Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery
Hidetaka Akita et al.
ACS BIOMATERIALS SCIENCE & ENGINEERING (2015)
Influence of cholesterol on liposome stability and on in vitro drug release
Maria-Lucia Briuglia et al.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2015)
Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery
Hidetaka Akita et al.
ACS BIOMATERIALS SCIENCE & ENGINEERING (2015)
CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation
Xin Han et al.
SCIENCE ADVANCES (2015)
Triggering of RNA Interference with RNA-RNA, RNA-DNA, and DNA-RNA Nanoparticles
Kirill A. Afonin et al.
ACS NANO (2015)
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EXPERT REVIEW OF VACCINES (2015)
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Gemini Surfactants Based on Bis-Imidazolium Alkoxy Derivatives as Effective Agents for Delivery of Nucleic Acids: A Structural and Spectroscopic Study
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
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ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 16 (2014)
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Gijs Koopmanschap et al.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2014)
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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2014)
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Kasper Bendix Johnsen et al.
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Ling-Yan Gao et al.
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Yang Ding et al.
BIOMATERIALS (2014)
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Qiao-ling Zhu et al.
BIOMATERIALS (2014)
Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing
Qiurong Ding et al.
CIRCULATION RESEARCH (2014)
Cholesterol precursors: more than mere markers of biosynthesis
Andrew J. Brown et al.
CURRENT OPINION IN LIPIDOLOGY (2014)
An efficient method for long-term room temperature storage of RNA
Anne-Lise Fabre et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2014)
VCAM-1 specific PEGylated SAINT-based lipoplexes deliver siRNA to activated endothelium in vivo but do not attenuate target gene expression
Niek G. J. Leus et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)
Lipopolyplexes comprising imidazolefimidazolium lipophosphoramidate, histidinylated polyethyleneimine and siRNA as efficient formulation for siRNA transfection
Cristine Goncalves et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)
First-in-Human Phase I Study of the Liposomal RNA Interference Therapeutic Atu027 in Patients With Advanced Solid Tumors
Beate Schultheis et al.
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Sougata Datta et al.
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Designer lipids for drug delivery: From heads to tails
Aditya G. Kohli et al.
JOURNAL OF CONTROLLED RELEASE (2014)
Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo
Piotr S. Kowalski et al.
JOURNAL OF CONTROLLED RELEASE (2014)
Target-specific delivery of siRNA by stabilized calcium phosphate nanoparticles using dopa-hyaluronic acid conjugate
Min Sang Lee et al.
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A novel cationic niosome formulation for gene delivery to the retina
G. Puras et al.
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Cell-Type-Specific Aptamer and Aptamer-Small Interfering RNA Conjugates for Targeted Human Immunodeficiency Virus Type 1 Therapy
Jiehua Zhou et al.
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Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
Jayaprakash K. Nair et al.
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Yvonne Goepel et al.
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Stabilization of Ostwald Ripening in Low Molecular Weight Amino Lipid Nanoparticles for Systemic Delivery of siRNA Therapeutics
Marian E. Gindy et al.
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Multifunctional Cationic Lipid-Based Nanoparticles Facilitate Endosomal Escape and Reduction-Triggered Cytosolic siRNA Release
Maneesh Gujrati et al.
MOLECULAR PHARMACEUTICS (2014)
A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines
Luis A. Brito et al.
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Thomas F. Martens et al.
NANO TODAY (2014)
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Gemma Navarro et al.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2014)
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Hao Yin et al.
NATURE BIOTECHNOLOGY (2014)
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
James E. Dahlman et al.
NATURE NANOTECHNOLOGY (2014)
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NATURE REVIEWS DRUG DISCOVERY (2014)
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Hao Yin et al.
NATURE REVIEWS GENETICS (2014)
Heterocyclic Cationic Gemini Surfactants: A Comparative Overview of Their Synthesis, Self-assembling, Physicochemical, and Biological Properties
Vishnu Dutt Sharma et al.
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Antisense Oligonucleotides Capable of Promoting Specific Target mRNA Reduction via Competing RNase H1-Dependent and Independent Mechanisms
Timothy A. Vickers et al.
PLOS ONE (2014)
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Yizhou Dong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes
Jiahai Shi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
Kathryn A. Whitehead et al.
NATURE COMMUNICATIONS (2014)
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Fritz Eckstein
NUCLEIC ACID THERAPEUTICS (2014)
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Tsunamasa Watanabe et al.
SCIENTIFIC REPORTS (2014)
Enhanced Intracellular siRNA Delivery using Bioreducible Lipid-Like Nanoparticles
Ming Wang et al.
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Masami Ukawa et al.
ADVANCED HEALTHCARE MATERIALS (2014)
Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo
Yizhou Dong et al.
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Tamoxifen embedded in lipid bilayer improves the oncotarget of liposomal daunorubicin in vivo
M. H. Li et al.
JOURNAL OF MATERIALS CHEMISTRY B (2014)
Cationic gemini lipids containing polyoxyethylene spacers as improved transfecting agents of plasmid DNA in cancer cells
Ana L. Barran-Berdon et al.
JOURNAL OF MATERIALS CHEMISTRY B (2014)
Lipid nanoparticle delivery systems for siRNA-based therapeutics
C. Wan et al.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2014)
Mechanism of Polyplex- and Lipoplex-Mediated Delivery of Nucleic Acids: Real-Time Visualization of Transient Membrane Destabilization without Endosomal Lysis
Zia Ur Rehman et al.
ACS NANO (2013)
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Theresa M. Allen et al.
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Samir EL Andaloussi et al.
ADVANCED DRUG DELIVERY REVIEWS (2013)
Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery
Yunlong Zhang et al.
ADVANCED MATERIALS (2013)
The role of the helper lipid dioleoylphosphatidylethanolamine (DOPE) for DNA transfection cooperating with a cationic lipid bearing ethylenediamine
Shinichi Mochizuki et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2013)
Synthesis, Characterization, and Evaluation of Ionizable Lysine-Based Lipids for siRNA Delivery
Colin L. Walsh et al.
BIOCONJUGATE CHEMISTRY (2013)
The Headgroup Evolution of Cationic Lipids for Gene Delivery
Defu Zhi et al.
BIOCONJUGATE CHEMISTRY (2013)
The Polyethyleneglycol Dilemma: Advantage and Disadvantage of PEGylation of Liposomes for Systemic Genes and Nucleic Acids Delivery to Tumors
Hiroto Hatakeyama et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2013)
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Yuan Zhang et al.
BIOMATERIALS (2013)
Interfacial engineering of pyridinium gemini surfactants for the generation of synthetic transfection systems
Vishnu D. Sharma et al.
BIOMATERIALS (2013)
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Zhi-Yi Chen et al.
CARDIOVASCULAR ULTRASOUND (2013)
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
Haoyi Wang et al.
CELL (2013)
Phospholipid-Detergent Conjugates as Novel Tools for siRNA Delivery
Philippe Pierrat et al.
CHEMISTRY-A EUROPEAN JOURNAL (2013)
In-Vivo Gene Delivery by Sonoporation: Recent Progress and Prospects
Jean-Michel Escoffre et al.
CURRENT GENE THERAPY (2013)
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Xinmei Wang et al.
JOURNAL OF CONTROLLED RELEASE (2013)
Nanostructured lipid carriers as multifunctional nanomedicine platform for pulmonary co-delivery of anticancer drugs and siRNA
Oleh Taratula et al.
JOURNAL OF CONTROLLED RELEASE (2013)
Design and evaluation of new pH-sensitive amphiphilic cationic lipids for siRNA delivery
Anthony S. Malamas et al.
JOURNAL OF CONTROLLED RELEASE (2013)
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Zia Ur Rehman et al.
JOURNAL OF CONTROLLED RELEASE (2013)
Efficient delivery of therapeutic small nucleic acids to prostate cancer cells using ketal nucleoside lipid nanoparticles
Delphine Luvino et al.
JOURNAL OF CONTROLLED RELEASE (2013)
Dual-Responsive Surfaces Modified with Phenylboronic Acid-Containing Polymer Brush To Reversibly Capture and Release Cancer Cells
Hongliang Liu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
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Leiming Li et al.
MOLECULAR CANCER THERAPEUTICS (2013)
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Piotr S. Kowalski et al.
MOLECULAR PHARMACEUTICS (2013)
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Richard D. Harvey et al.
MOLECULAR PHARMACEUTICS (2013)
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Martin A. Maier et al.
MOLECULAR THERAPY (2013)
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Yu Sakurai et al.
MOLECULAR THERAPY (2013)
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Paulo J. C. Lin et al.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2013)
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Shu-hao Hsu et al.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2013)
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Jerome Gilleron et al.
NATURE BIOTECHNOLOGY (2013)
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Lior Zangi et al.
NATURE BIOTECHNOLOGY (2013)
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
Gaurav Sahay et al.
NATURE BIOTECHNOLOGY (2013)
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Rosemary Kanasty et al.
NATURE MATERIALS (2013)
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Samir EL Andaloussi et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Rat Brain-Uptake Index for Phenylethylamine and Various Monomethylated Derivatives
Aron D. Mosnaim et al.
NEUROCHEMICAL RESEARCH (2013)
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Haitang Wang et al.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2013)
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Ekaterina A. Ivanova et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2013)
Bioresponsive Deciduous-Charge Amphiphiles for Liposomal Delivery of DNA and siRNA
Philippe Pierrat et al.
PHARMACEUTICAL RESEARCH (2013)
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Christopher A. Alabi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
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Xiaoyang Xu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
A vector-free microfluidic platform for intracellular delivery
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
RNA-Based Tools for Nuclear Reprogramming and Lineage-Conversion: Towards Clinical Applications
Juan A. Bernal
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2013)
A Neutral Envelope-Type Nanoparticle Containing pH-Responsive and SS-Cleavable Lipid-Like Material as a Carrier for Plasmid DNA
Hidetaka Akita et al.
ADVANCED HEALTHCARE MATERIALS (2013)
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Laura Russo et al.
BIOMED RESEARCH INTERNATIONAL (2013)
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Lara Prosen et al.
BIOMED RESEARCH INTERNATIONAL (2013)
Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
Armon Sharei et al.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2013)
Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles
Barbara L. Mui et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2013)
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Ravi L. Rungta et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2013)
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Yuen Tam et al.
Pharmaceutics (2013)
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Scott A. Barros et al.
ADVANCED DRUG DELIVERY REVIEWS (2012)
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Caroline Lonez et al.
ADVANCED DRUG DELIVERY REVIEWS (2012)
Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery
Fangqiong Tang et al.
ADVANCED MATERIALS (2012)
An Amphiphilic Dendrimer for Effective Delivery of Small Interfering RNA and Gene Silencing In Vitro and In Vivo
Tianzhu Yu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
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Muthusamy Jayaraman et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Transfection efficiency boost of cholesterol-containing lipoplexes
Daniela Pozzi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2012)
Mechanistic Insights into LDL Nanoparticle-Mediated siRNA Delivery
Honglin Jin et al.
BIOCONJUGATE CHEMISTRY (2012)
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Monica Munoz-Ubeda et al.
BIOMACROMOLECULES (2012)
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Bo Yu et al.
BIOMATERIALS (2012)
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Colin L. Walsh et al.
CHEMICAL COMMUNICATIONS (2012)
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Justin B. Lee et al.
INTERNATIONAL JOURNAL OF CANCER (2012)
Efficient and safe delivery of siRNA using anionic lipids: Formulation optimization studies
Mamta Kapoor et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)
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Tao Wang et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)
Calcium phosphate nanoparticles with an asymmetric lipid bilayer coating for siRNA delivery to the tumor
Jun Li et al.
JOURNAL OF CONTROLLED RELEASE (2012)
A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo
Yusuke Sato et al.
JOURNAL OF CONTROLLED RELEASE (2012)
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Yechezkel (Chezy) Barenholz
JOURNAL OF CONTROLLED RELEASE (2012)
Small-Angle Neutron-Scattering Studies of Mixed Micellar Structures Made of Dimeric Surfactants Having Imidazolium and Ammonium Headgroups
Asish Pal et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2012)
Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation
Delai Chen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Pendant Polymer:Amino-β-Cyclodextrin:siRNA Guest:Host Nanoparticles as Efficient Vectors for Gene Silencing
Aditya Kulkarni et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Gemini Imidazolium Surfactants: Synthesis and Their Biophysiochemical Study
Raman Kamboj et al.
LANGMUIR (2012)
SPANosomes as Delivery Vehicles for Small Interfering RNA (siRNA)
Chenguang Zhou et al.
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Abdelkader A. Metwally et al.
MOLECULAR PHARMACEUTICS (2012)
Asymmetrical N4,N9-Diacyl Spermines: SAR Studies of Nonviral Lipopolyamine Vectors for Efficient siRNA Delivery with Silencing of EGFP Reporter Gene
Ian S. Blagbrough et al.
MOLECULAR PHARMACEUTICS (2012)
Glycerol Monooleate-Based Nanocarriers for siRNA Delivery in Vitro
Guoliang Zhen et al.
MOLECULAR PHARMACEUTICS (2012)
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Michael D. Pungente et al.
MOLECULES (2012)
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Ryszard Kole et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes
Jessica Wahlgren et al.
NUCLEIC ACIDS RESEARCH (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
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SCIENCE (2012)
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Adrian G. Torres et al.
TRENDS IN BIOTECHNOLOGY (2012)
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Plant pentacyclic triterpenic acids as modulators of lipid membrane physical properties
Jesus Prades et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2011)
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J. P. Neves Silva et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2011)
A Molecular Umbrella Approach to the Intracellular Delivery of Small Interfering RNA
Lauren L. Cline et al.
BIOCONJUGATE CHEMISTRY (2011)
Dicetyl Phosphate-Tetraethylenepentamine-Based Liposomes for Systemic siRNA Delivery
Tomohiro Asai et al.
BIOCONJUGATE CHEMISTRY (2011)
Galactose-Modified Cationic Liposomes as a Liver-Targeting Delivery System for Small Interfering RNA
Satoru Sonoke et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2011)
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Rae Sung Chang et al.
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Joe Liu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
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J. A. Broderick et al.
GENE THERAPY (2011)
Novel RGD-lipid conjugate-modified liposomes for enhancing siRNA delivery in human retinal pigment epithelial cells
Cheng-Wei Chen et al.
INTERNATIONAL JOURNAL OF NANOMEDICINE (2011)
Tryptamine-Induced Tryptophanyl-tRNA(trp) Deficiency in Neurodifferentiation and Neurodegeneration Interplay: Progenitor Activation with Neurite Growth Terminated in Alzheimer's Disease Neuronal Vesicularization and Fragmentation
Elena L. Paley
JOURNAL OF ALZHEIMERS DISEASE (2011)
Endosomal escape pathways for delivery of biologicals
Amir K. Varkouhi et al.
JOURNAL OF CONTROLLED RELEASE (2011)
Glioma-initiating cells: A predominant role in microglia/macrophages tropism to glioma
Liang Yi et al.
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Interaction of Cholesterol-Conjugated Ionizable Amino Lipids with Biomembranes: Lipid Polymorphism, Structure-Activity Relationship, and Implications for siRNA Delivery
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LANGMUIR (2011)
Nanogyroids Incorporating Multivalent Lipids: Enhanced Membrane Charge Density and Pore Forming Ability for Gene Silencing
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LANGMUIR (2011)
Ionization Behavior of Amino Lipids for siRNA Delivery: Determination of Ionization Constants, SAR, and the Impact of Lipid pKa on Cationic Lipid-Biomembrane Interactions
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LANGMUIR (2011)
Mannose-Functionalized Pathogen-like Polyanhydride Nanoparticles Target C-Type Lectin Receptors on Dendritic Cells
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MOLECULAR PHARMACEUTICS (2011)
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MOLECULAR PHARMACEUTICS (2011)
Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses
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MOLECULAR THERAPY (2011)
Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells
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MOLECULAR THERAPY (2011)
An Amino Acid-based Amphoteric Liposomal Delivery System for Systemic Administration of siRNA
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MOLECULAR THERAPY (2011)
Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice
Phong Trang et al.
MOLECULAR THERAPY (2011)
Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA
Federico Perche et al.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Lydia Alvarez-Erviti et al.
NATURE BIOTECHNOLOGY (2011)
Photoporation of Biomolecules into Single Cells in Living Vertebrate Embryos Induced by a Femtosecond Laser Amplifier
Yoichiroh Hosokawa et al.
PLOS ONE (2011)
Efficient Cytosolic Delivery of siRNA Using HDL-Mimicking Nanoparticles
Mi Yang et al.
SMALL (2011)
Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials
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SMALL (2011)
Enhanced Chemotherapy Efficacy by Sequential Delivery of siRNA and Anticancer Drugs Using PEI-Grafted Graphene Oxide
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SMALL (2011)
Platelet-derived microparticles - an updated perspective
Pia R. M. Siljander
THROMBOSIS RESEARCH (2011)
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells
Maria Mittelbrunn et al.
NATURE COMMUNICATIONS (2011)
Polymers in Small-Interfering RNA Delivery
Kaushik Singha et al.
NUCLEIC ACID THERAPEUTICS (2011)
Efficient Gene Silencing by Self-Assembled Complexes of siRNA and Symmetrical Fatty Acid Amides of Spermine
Abdelkader A. Metwally et al.
Pharmaceutics (2011)
Self-Assembled Lipoplexes of Short Interfering RNA (siRNA) Using Spermine-Based Fatty Acid Amide Guanidines: Effect on Gene Silencing Efficiency
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Pharmaceutics (2011)
Assessment of Tumor Metastasis by the Direct Determination of Cell-Membrane Sialic Acid Expression
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Thiol-Yne Chemistry: A Powerful Tool for Creating Highly Functional Materials
Richard Hoogenboom
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
C. Frank Bennett et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2010)
Combinatorial Approach to Determine Functional Group Effects on Lipidoid-Mediated siRNA Delivery
Kerry P. Mahon et al.
BIOCONJUGATE CHEMISTRY (2010)
Transfection Efficiency of Cationic Lipids with Different Hydrophobic Domains in Gene Delivery
DeFu Zhi et al.
BIOCONJUGATE CHEMISTRY (2010)
Cationic Nucleoside Lipids Derived from Universal Bases: A Rational Approach for siRNA Transfection
Claire Ceballos et al.
BIOCONJUGATE CHEMISTRY (2010)
The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation
Ranit Kedmi et al.
BIOMATERIALS (2010)
Mechanisms of nucleotide trafficking during siRNA delivery to endothelial cells using perfluorocarbon nanoemulsions
Megan M. Kaneda et al.
BIOMATERIALS (2010)
Development of a Lung Cancer Therapeutic Based on the Tumor Suppressor MicroRNA-34
Jason F. Wiggins et al.
CANCER RESEARCH (2010)
Synthesis and delivery activity of new cationic cholesteryl glucosides
Mikhail A. Maslov et al.
CARBOHYDRATE RESEARCH (2010)
Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models
Ansgar Santel et al.
CLINICAL CANCER RESEARCH (2010)
Gene delivery by lipoplexes and polyplexes
Conchita Tros de Ilarduya et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2010)
DC-Chol/DOPE cationic liposomes: A comparative study of the influence factors on plasmid pDNA and siRNA gene delivery
Yang Zhang et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)
Multifunctional Nanoparticles Delivering Small Interfering RNA and Doxorubicin Overcome Drug Resistance in Cancer
Yunching Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
DODAG; a versatile new cationic lipid that mediates efficient delivery of pDNA and siRNA
Mathieu Mevel et al.
JOURNAL OF CONTROLLED RELEASE (2010)
Highly Efficient Gene Silencing Activity of siRNA Embedded in a Nanostructured Gyroid Cubic Lipid Matrix
Cecilia Leal et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Tailoring Lipoplex Composition to the Lipid Composition of Plasma Membrane: A Trojan Horse for Cell Entry?
Cristina Marchini et al.
LANGMUIR (2010)
Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment
Marc T. Abrams et al.
MOLECULAR THERAPY (2010)
Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms
Akin Akinc et al.
MOLECULAR THERAPY (2010)
Noninvasive Imaging of Lipid Nanoparticle-Mediated Systemic Delivery of Small-Interfering RNA to the Liver
Weikang Tao et al.
MOLECULAR THERAPY (2010)
Polymer- and lipid-based nanoparticle therapeutics for the treatment of liver diseases
Lanjuan Li et al.
NANO TODAY (2010)
Rational design of cationic lipids for siRNA delivery
Sean C. Semple et al.
NATURE BIOTECHNOLOGY (2010)
The emerging field of RNA nanotechnology
Peixuan Guo
NATURE NANOTECHNOLOGY (2010)
Aptamers as therapeutics
Anthony D. Keefe et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Sensors and regulators of intracellular pH
Joseph R. Casey et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Lipid-like materials for low-dose, in vivo gene silencing
Kevin T. Love et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Functional delivery of viral miRNAs via exosomes
D. Michiel Pegtel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Nanotoxicity of pure silica mediated through oxidant generation rather than glutathione depletion in human lung epithelial cells
Mohd Javed Akhtar et al.
TOXICOLOGY (2010)
Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates
Gary B. Braun et al.
ACS NANO (2009)
Polyethyleneimine Coating Enhances the Cellular Uptake of Mesoporous Silica Nanoparticles and Allows Safe Delivery of siRNA and DNA Constructs
Tian Xia et al.
ACS NANO (2009)
Lipid-Like Nanoparticles for Small Interfering RNA Delivery to Endothelial Cells
Seung-Woo Cho et al.
ADVANCED FUNCTIONAL MATERIALS (2009)
All-in-One Target-Cell-Specific Magnetic Nanoparticles for Simultaneous Molecular Imaging and siRNA Delivery
Jae-Hyun Lee et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Ligand-Targeted Delivery of Small Interfering RNAs to Malignant Cells and Tissues
Mini Thomas et al.
OLIGONUCLEOTIDE THERAPEUTICS (2009)
Cationic Nucleoside Lipids Based on a 3-Nitropyrrole Universal Base for siRNA Delivery
Claire Ceballos et al.
BIOCONJUGATE CHEMISTRY (2009)
Addressing the problem of cationic lipid-mediated toxicity: The magnetoliposome model
Stefaan J. H. Soenen et al.
BIOMATERIALS (2009)
A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulation
Xiufen Zheng et al.
BLOOD (2009)
Nonviral Vectors for Gene Delivery
Meredith A. Mintzer et al.
CHEMICAL REVIEWS (2009)
A modified protocol for efficient DNA encapsulation into pegylated immunoliposomes (PILs)
Tina Skjorringe et al.
JOURNAL OF CONTROLLED RELEASE (2009)
Anionic amino acid-derived cationic lipid for siRNA delivery
Min Sung Suh et al.
JOURNAL OF CONTROLLED RELEASE (2009)
Bioactive sphingolipids: metabolism and function
Nana Bartke et al.
JOURNAL OF LIPID RESEARCH (2009)
Noninvasive Sialic Acid Detection at Cell Membrane by Using Phenylboronic Acid Modified Self-Assembled Monolayer Gold Electrode
Akira Matsumoto et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Mesomorphic Imidazolium Salts: New Vectors for Efficient siRNA Transfection
William Dobbs et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Gene Regulation with Polyvalent siRNA-Nanoparticle Conjugates
David A. Giljohann et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Novel Gemini Pyridinium Surfactants: Synthesis and Study of Their Surface Activity, DNA Binding, and Cytotoxicity
Avinash Bhadani et al.
LANGMUIR (2009)
Novel Cationic Lipid That Delivers siRNA and Enhances Therapeutic Effect in Lung Cancer Cells
Yunching Chen et al.
MOLECULAR PHARMACEUTICS (2009)
Formulation and Delivery of siRNA by Oleic Acid and Stearic Acid Modified Polyethylenimine
Aws Alshamsan et al.
MOLECULAR PHARMACEUTICS (2009)
A Novel Mechanism Is Involved in Cationic Lipid-Mediated Functional siRNA Delivery
James J. Lu et al.
MOLECULAR PHARMACEUTICS (2009)
Drug Delivery-mediated Control of RNA Immunostimulation
David N. Nguyen et al.
MOLECULAR THERAPY (2009)
Development of Lipidoid-siRNA Formulations for Systemic Delivery to the Liver
Akin Akinc et al.
MOLECULAR THERAPY (2009)
Thiol-Yne Photopolymerizations: Novel Mechanism, Kinetics, and Step-Growth Formation of Highly Cross-Linked Networks
Benjamin D. Fairbanks et al.
MACROMOLECULES (2009)
Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein
Akiko Eguchi et al.
NATURE BIOTECHNOLOGY (2009)
Knocking down barriers: advances in siRNA delivery
Kathryn A. Whitehead et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Transfer of MicroRNAs by Embryonic Stem Cell Microvesicles
Alex Yuan et al.
PLOS ONE (2009)
Very Long Chain N-4 ,N-9 -Diacyl Spermines: Non-Viral Lipopolyamine Vectors for Efficient Plasmid DNA and siRNA Delivery
Hassan M. Ghonaim et al.
PHARMACEUTICAL RESEARCH (2009)
Locked nucleic acid as a novel class of therapeutic agents
Rakesh N. Veedu et al.
RNA BIOLOGY (2009)
Self-assembled lipid-polymer hybrid nanoparticles: A robust drug delivery platform
Liangfang Zhang et al.
ACS NANO (2008)
Gold nanoparticles in delivery applications
Partha Ghosh et al.
ADVANCED DRUG DELIVERY REVIEWS (2008)
Catalytic three-component Ugi reaction
Subhas Chandra Pan et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
Focusing on clathrin-mediated endocytosis
Joshua Z. Rappoport
BIOCHEMICAL JOURNAL (2008)
Cellular internalization and distribution of arginine-rich peptides as a function of extracellular peptide concentration, serum, and plasma membrane associated proteoglycans
Michie Kosuge et al.
BIOCONJUGATE CHEMISTRY (2008)
Evaluation of cationic assemblies constructed with amino acid based lipids for plasmid DNA delivery
Yosuke Obata et al.
BIOCONJUGATE CHEMISTRY (2008)
A multifunctional and reversibly polymerizable carrier for efficient siRNA delivery
Xu-Li Wang et al.
BIOMATERIALS (2008)
Tumor Regression in Mice by Delivery of Bcl-2 Small Interfering RNA with Pegylated Cationic Liposomes
Satoru Sonoke et al.
CANCER RESEARCH (2008)
Atu027, a Liposomal Small Interfering RNA Formulation Targeting Protein Kinase N3, Inhibits Cancer Progression
Manuela Aleku et al.
CANCER RESEARCH (2008)
Microinjection as a tool of mechanical delivery
Yan Zhang et al.
CURRENT OPINION IN BIOTECHNOLOGY (2008)
Electroporation as an efficient method of gene transfer
Noritaka Odani et al.
DEVELOPMENT GROWTH & DIFFERENTIATION (2008)
Mannose-targeted systems for the delivery of therapeutics
Juan M. Irache et al.
EXPERT OPINION ON DRUG DELIVERY (2008)
Stability of luciferase plasmid entrapped in cationic bilayer vesicles
A. Manosroi et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)
Two-dimensional self-assembly and complementary base-pairing between amphiphile nucleotides on graphite
Isabelle Bestel et al.
JOURNAL OF COLLOID AND INTERFACE SCIENCE (2008)
Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles
Shyh-Dar Li et al.
JOURNAL OF CONTROLLED RELEASE (2008)
Synergistic antitumoral effect of vinblastine and HSV-Tk/GCV gene therapy mediated by albumin-associated cationic liposomes
H. Faneca et al.
JOURNAL OF CONTROLLED RELEASE (2008)
Efficient targeting to alveolar macrophages by intratracheal administration of mannosylated liposomes in rats
Wassana Wijagkanalan et al.
JOURNAL OF CONTROLLED RELEASE (2008)
Coating didodecyldimethylammonium bromide onto Au nanoparticles increases the stability of its complex with DNA
Peicai Li et al.
JOURNAL OF CONTROLLED RELEASE (2008)
Sterol-Modified Phospholipids: Cholesterol and Phospholipid Chimeras with Improved Biomembrane Properties
Zhaohua Huang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Assessing siRNA Pharmacodynamics in a Luciferase-expressing Mouse
Robert U. Svensson et al.
MOLECULAR THERAPY (2008)
Efficient in vivo delivery of siRNA to the liver by conjugation of α-tocopherol
Kazutaka Nishina et al.
MOLECULAR THERAPY (2008)
Microfluidic platform for controlled synthesis of polymeric nanoparticles
Rohit Karnik et al.
NANO LETTERS (2008)
The effect of cetyl palmitate crystallinity on physical properties of gamma-oryzanol encapsulated in solid lipid nanoparticles
Uracha Ruktanonchai et al.
NANOTECHNOLOGY (2008)
Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone
Yasushi Sato et al.
NATURE BIOTECHNOLOGY (2008)
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
Akin Akinc et al.
NATURE BIOTECHNOLOGY (2008)
Protein therapeutics: A summary and pharmacological classification
Benjamin Leader et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Cellular cholesterol trafficking and compartmentalization
Elina Ikonen
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Principles of bioactive lipid signalling: lessons from sphingolipids
Yusuf A. Hannun et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
NPC1/NPC2 function as a tag team duo to mobilize cholesterol
Kanagaraj Subramanian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
Maria Frank-Kamenetsky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Nucleic acid delivery: Where material sciences and bio-sciences meet
Katrien Remaut et al.
MATERIALS SCIENCE & ENGINEERING R-REPORTS (2007)
Novel polymerizable surfactants with pH-sensitive amphiphilicity and cell membrane disruption for efficient siRNA delivery
Xu-Li Wang et al.
BIOCONJUGATE CHEMISTRY (2007)
Design of targeted lipid nanocapsules by conjugation of whole antibodies and antibody Fab' fragments
Arnaud Beduneau et al.
BIOMATERIALS (2007)
Acid-free, aminoborane-mediated Ugi-type reaction leading to general utilization of secondary Amines
Yusuke Tanaka et al.
ORGANIC LETTERS (2007)
Self-assembled lamellar complexes of siRNA with lipidic aminoglycoside derivatives promote efficient siRNA delivery and interference
Lea Desigaux et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Cationic liposornes as vaccine adjuvants
Dennis Christensen et al.
EXPERT REVIEW OF VACCINES (2007)
Nucleolipoplexes: A new paradigm for phospholipid bilayer-nucleic acid interactions
Silvia Milani et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Dicationic lipophosphoramidates as DNA carriers
Mathieu Mevel et al.
BIOCONJUGATE CHEMISTRY (2007)
Design and creation of new nanomaterials for therapeutic RNAi
Huricha Baigude et al.
ACS CHEMICAL BIOLOGY (2007)
Employment of cationic solid-lipid nanoparticles as RNA carriers
Giovanna Montana et al.
BIOCONJUGATE CHEMISTRY (2007)
In vivo imaging of siRNA delivery and silencing in tumors
Zdravka Medarova et al.
NATURE MEDICINE (2007)
Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery: Influence of the synthesis parameters on transfection efficiency
Dana Olton et al.
BIOMATERIALS (2007)
Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems
Brian G. Trewyn et al.
CHEMICAL COMMUNICATIONS (2007)
Phase behavior of gemini surfactants
Martin In et al.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY (2007)
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
Hadi Valadi et al.
NATURE CELL BIOLOGY (2007)
Cationic lipids, lipoplexes and intracellular delivery of genes
Luc Wasungu et al.
JOURNAL OF CONTROLLED RELEASE (2006)
In vitro and in vivo gene-transferring characteristics of novel cationic lipids, DMKD (O,O′-dimyristyl-N-lysyl aspartate) and DMKE (O,O′-dimyristyl-N-lysyl glutamate)
Hong Sung Kim et al.
JOURNAL OF CONTROLLED RELEASE (2006)
Cubic phases in phosphatidylcholine-cholesterol mixtures: Cholesterol as membrane fusogen''
Boris G. Tenchov et al.
BIOPHYSICAL JOURNAL (2006)
Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma
Won Jong Kim et al.
MOLECULAR THERAPY (2006)
Engineering mucosal RNA interference in vivo
Yingjie Zhang et al.
MOLECULAR THERAPY (2006)
RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy
A. Santel et al.
GENE THERAPY (2006)
A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium
A. Santel et al.
GENE THERAPY (2006)
Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras
James O. McNamara et al.
NATURE BIOTECHNOLOGY (2006)
Lipophilic pyrylium salts in the synthesis of efficient pyridinium-based cationic lipids, gemini surfactants, and lipophilic oligomers for gene delivery
Marc Antoniu Ilies et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Mannosylated liposomes as antigen delivery vehicles for targeting to dendritic cells
Karen L. White et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2006)
RNAi-mediated gene silencing in non-human primates
TS Zimmermann et al.
NATURE (2006)
New ionic liquid crystals based on imidazolium salts
W Dobbs et al.
NEW JOURNAL OF CHEMISTRY (2006)
siRNA-based approaches in cancer therapy
G. R. Devi
CANCER GENE THERAPY (2006)
Varying the unsaturation in N-4,N-9-dioctadecanoyl spermines: Nonviral lipopolyamine vectors for more efficient plasmid DNA formulation
OAA Ahmed et al.
PHARMACEUTICAL RESEARCH (2006)
Arginine-rich motifs present multiple interfaces for specific binding by RNA
TS Bayer et al.
RNA (2005)
EphA2 as a target for ovarian cancer therapy
CN Landen et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2005)
The role of dioleoylphosphaticlylethanolamine (DOPE) in targeted gene delivery with mannosylated cationic liposomes via intravenous route
Y Hattori et al.
JOURNAL OF CONTROLLED RELEASE (2005)
Mesomorphic complexes of DNA with the mixtures of a cationic surfactant and a neutral lipid
WL Hsu et al.
LANGMUIR (2005)
Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids
J Heyes et al.
JOURNAL OF CONTROLLED RELEASE (2005)
Synthesis of cationic cardiolipin analogues
K Kasireddy et al.
BIOORGANIC CHEMISTRY (2005)
Hydrolytic degradation of poly(ethylene oxide)-block-polycaprolactone worm micelles
Y Geng et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Nucleoside phosphocholine amphiphile for in vitro DNA transfection
L Moreau et al.
MOLECULAR BIOSYSTEMS (2005)
Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery
CN Landen et al.
CANCER RESEARCH (2005)
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
EW Song et al.
NATURE BIOTECHNOLOGY (2005)
N4,N9-dioleoyl spermine is a novel nonviral lipopolyamine vector for plasmid DNA formulation
OAA Ahmed et al.
PHARMACEUTICAL RESEARCH (2005)
Nonbilayer phase of lipoplex-membrane mixture determines endosomal escape of genetic cargo and transfection efficiency
IS Zuhorn et al.
MOLECULAR THERAPY (2005)
Water insoluble and soluble lipids for gene delivery
RI Mahato
ADVANCED DRUG DELIVERY REVIEWS (2005)
Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity
JS Zhang et al.
ADVANCED DRUG DELIVERY REVIEWS (2005)
Vesicle formation from a synthetic adenosine based lipid
L Moreau et al.
TETRAHEDRON LETTERS (2005)
RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
B Urban-Klein et al.
GENE THERAPY (2005)
Pyridinium cationic lipids in gene delivery: an in vitro and in vivo comparison of transfection efficiency versus a tetraalkylammonium congener
MA Ilies et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)
Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo
PY Chien et al.
CANCER GENE THERAPY (2005)
2-deoxystreptamine: Central scaffold of aminoglycoside antibiotics
GF Busscher et al.
CHEMICAL REVIEWS (2005)
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling
C Le Roy et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
A straightforward approach towards thiazoles and endothiopeptides via Ugi reaction
U Kazmaier et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2005)
Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding
B Francois et al.
NUCLEIC ACIDS RESEARCH (2005)
Smart delivery of antisense oligonucleotides by anionic pH-sensitive liposomes
E Fattal et al.
ADVANCED DRUG DELIVERY REVIEWS (2004)
Direct organocatalytic asymmetric α-chlorination of aldehydes
N Halland et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Rational siRNA design for RNA interference
A Reynolds et al.
NATURE BIOTECHNOLOGY (2004)
Relationship between sterol/steroid structure and participation in ordered lipid domains (lipid rafts): Implications for lipid raft structure and function
JW Wang et al.
BIOCHEMISTRY (2004)
Solid-phase synthesis of 89 polyamine-based cationic lipids for DNA delivery to mammalian cells
B Yingyongnarongkul et al.
CHEMISTRY-A EUROPEAN JOURNAL (2004)
Gene therapy progress and prospects: Electroporation and other physical methods
DJ Wells
GENE THERAPY (2004)
Membrane properties of plant sterols in phospholipid bilayers as determined by differential scanning calorimetry, resonance energy transfer and detergent-induced solubilization
KK Halling et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2004)
Spacer-arm modulated gene delivery efficacy of novel cationic glycolipids: Design, synthesis, and in vitro transfection biology
YV Mahidhar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Seeing the gene therapy: application of gene gun technique to transfect and decolour pigmented rat skin with human agouti signalling protein cDNA
CH Yang et al.
GENE THERAPY (2004)
Cellular uptake of arginine-rich peptides: Roles for macropinocytosis and actin rearrangement
I Nakase et al.
MOLECULAR THERAPY (2004)
DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery: zeta potential measurements and electron spin resonance spectra
L Ciani et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2004)
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
J Soutschek et al.
NATURE (2004)
Association of albumin or protamine to lipoplexes: enhancement of transfection and resistance to serum
H Faneca et al.
JOURNAL OF GENE MEDICINE (2004)
Advanced transfection with Lipofectamine 2000 reagent: primary neurons, siRNA, and high-throughput applications
B Dalby et al.
METHODS (2004)
Aminoglycoside (neomycin) preference is for A-form nucleic acids, not just RNA: Results from a competition dialysis study
DP Arya et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Structure-activity relationship in cationic lipid mediated gene transfection
D Niculescu-Duvaz et al.
CURRENT MEDICINAL CHEMISTRY (2003)
Outpatient insulin therapy in type 1 and type 2 diabetes mellitus - Scientific review
DE DeWitt et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)
Anomalous binding profile of phenylboronic acid with N-acetylneuraminic acid (Neu5Ac) in aqueous solution with varying pH
H Otsuka et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Progress and prospects: naked DNA gene transfer and therapy
H Herweijer et al.
GENE THERAPY (2003)
Novel galactosylated polyamine bolaamphiphiles for gene delivery
K Fabio et al.
BIOCONJUGATE CHEMISTRY (2003)
Transfection mediated by gemini surfactants: Engineered escape from the endosomal compartment
PC Bell et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Stability of mRNA/cationic lipid lipoplexes in human and rat cerebrospinal fluid: Methods and evidence for nonviral mRNA gene delivery to the central nervous system
DM Anderson et al.
HUMAN GENE THERAPY (2003)
Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery
I Roy et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2003)
Gemini surfactants: New synthetic vectors for gene transfection
AJ Kirby et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)
Multi-component reactions : Emerging chemistry in drug discovery 'From xylocain to crixivan'
C Hulme et al.
CURRENT MEDICINAL CHEMISTRY (2003)
Efficient synthesis and cell-transfection properties of a new multivalent cationic lipid for nonviral gene delivery
K Ewert et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
In vivo characteristics of cationic liposomes as delivery vectors for gene therapy
SAL Audouy et al.
PHARMACEUTICAL RESEARCH (2002)
Triggered release of doxorubicin following mixing of cationic and anionic liposomes
IV Zhigaltsev et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2002)
Arginine-rich molecular transporters for drug delivery: Role of backbone spacing in cellular uptake
JB Rothbard et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Synthesis and properties of novel tetraalkyl cationic lipids
J Gaucheron et al.
BIOCONJUGATE CHEMISTRY (2002)
Efficient intracellular drug and gene delivery using folate receptor-targeted pH-sensitive liposomes composed of cationic/anionic lipid combinations
GF Shi et al.
JOURNAL OF CONTROLLED RELEASE (2002)
Synergy between cationic lipid and co-lipid determines the macroscopic structure and transfection activity of lipoplexes
ME Ferrari et al.
NUCLEIC ACIDS RESEARCH (2002)
Dimeric and oligomeric surfactants. Behavior at interfaces and in aqueous solution: a review
R Zana
ADVANCES IN COLLOID AND INTERFACE SCIENCE (2002)
Synthesis of novel cationic lipids: Effect of structural modification on the efficiency of gene transfer
JA Heyes et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Developments in liposomal drug delivery systems
N Maurer et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2001)
X-ray diffraction structures of some phosphatidylethanolamine lamellar and inverted hexagonal phases
PE Harper et al.
BIOPHYSICAL JOURNAL (2001)
Gene delivery with synthetic (non viral) carriers
MD Brown et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2001)
Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells
T Bettinger et al.
NUCLEIC ACIDS RESEARCH (2001)
Use of perfluorocarbon (Fluorinert) to enhance reporter gene expression following intratracheal instillation into the lungs of Balb/c mice: Implications for nebulized delivery of plasmids
A Das et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2001)
On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids
IM Hafez et al.
GENE THERAPY (2001)
A combinatorially-derived structural phase diagram for 42 zwitterionic geminis
FM Menger et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
SM Elbashir et al.
NATURE (2001)
Spontaneous entrapment of polynucleotides upon electrostatic interaction with ethanol-destabilized cationic liposomes
N Maurer et al.
BIOPHYSICAL JOURNAL (2001)
Ribozyme gene therapy: applications for molecular medicine
AS Lewin et al.
TRENDS IN MOLECULAR MEDICINE (2001)
Roles of lipid polymorphism in intracellular delivery
IM Hafez et al.
ADVANCED DRUG DELIVERY REVIEWS (2001)
RNA oligonucleotide synthesis via 5′-silyl-2′-orthoester chemistry
SA Scaringe
METHODS (2001)
Diquaternary ammonium compounds as transfection agents
HS Rosenzweig et al.
BIOCONJUGATE CHEMISTRY (2001)
Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures
SC Semple et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2001)
Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid: Plasmid DNA complexes in mice
JD Tousignant et al.
HUMAN GENE THERAPY (2000)
Cation substitution in cationic phosphonolipids:: A new concept to improve transfection activity and decrease cellular toxicity
V Floch et al.
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