期刊
CHEMICAL REVIEWS
卷 121, 期 13, 页码 7468-7529出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.0c01289
关键词
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资金
- National Key Research and Development Program of China [2020YFA0908200]
- National Natural Science Foundation of China [52073060, 61927805, 22002018]
- Launching Research Fund from Fudan University [JIH1340032, JIH1340038]
- Zhongshan-Xuhui Hospital
Microfluidics has emerged as a revolutionary technology in drug development, offering a miniaturized and highly controllable environment for efficient bio(chemical) reactions. This technology also enables integrated and high-throughput screening and evaluations, addressing challenges and showing promising prospects for future development in the field.
Drug development is a long process whose main content includes drug synthesis, drug delivery, and drug evaluation. Compared with conventional drug development procedures, microfluidics has emerged as a revolutionary technology in that it offers a miniaturized and highly controllable environment for bio(chemical) reactions to take place. It is also compatible with analytical strategies to implement integrated and high-throughput screening and evaluations. In this review, we provide a comprehensive summary of the entire microfluidics-based drug development system, from drug synthesis to drug evaluation. The challenges in the current status and the prospects for future development are also discussed. We believe that this review will promote communications throughout diversified scientific and engineering communities that will continue contributing to this burgeoning field.
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