期刊
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
卷 38, 期 4, 页码 856-865出版社
HIGHER EDUCATION PRESS
DOI: 10.1007/s40242-021-1265-5
关键词
Oligonucleotide; Peptide; Complex
资金
- National Key Research and Development Program of China [2019YFC1605900]
- National Natural Science Foundation of China [21922403, 21874034]
- Key Research and Development Project of Anhui Province, China [202104a07020013]
- Fundamental Research Funds for the Central Universities, China [JZ2021HGTA0171, JZ2021HGQA0243, PA2020GDJQ0030]
- Anhui Provincial Natural Science Foundation, China [2108085QB84]
This tutorial review comprehensively summarizes the synthesis strategies, characteristics, applications, challenges, and future perspectives of oligonucleotide-peptide complexes (OPCs). The article aims to boost researchers' interests in developing novel OPC synthesis techniques by providing a clear overview of the current situation and limitations in the field.
Nucleic acids form biological blueprint and polypeptides assist life activities, both of which are indispensable to organisms. Recently, oligonucleotide-peptide complexes (OPCs) have shown great potential in biomedicine, material chemistry and other fields due to their considerable stability and programmability. It remains a huge challenge to stably and facilely constructing OPCs that also limits the wide applications. This tutorial review first summarizes the synthesis strategies of OPC conjugation and the corresponding characteristics in detail, then gives examples of the applications of OPCs, and finally presents a prospective overview on challenges and future perspectives of OPCs. This review aims to help researchers understand the current situation and challenges in this field, thereby furthering interests in developing novel OPC synthesis techniques.
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