Fe-Catalysed Coupling Reactions Between Alkynes and Alcohols

In this review, we discussed about the synthetic developments in the field of Fe-catalysis for the formation of - bonds through the coupling of alkynes and alcohols, for the period of 13 years (2008-2020). These strategies fulfil important Green Chemistry principles, as they are highly atom economic (up to 100 %), no toxic by-products (only water), employs highly abundant and low toxic alcohols (no need for any pre-functionalization hence step economy) and cheaper Fe-catalysts. Having these advantages, one can predict that in the coming years a large number of fascinating new iron-catalyzed reactions will be developed for the organic synthesis. We hope that this review article will be highly useful for the synthetic community to design and develop new Fe-catalyzed coupling reactions and keeps the content in the right prospect.

Automated summary

This review discusses the synthetic developments in Fe-catalysis over the past 13 years, focusing on the coupling of alkynes and alcohols to form bonds. These strategies adhere to Green Chemistry principles and are predicted to lead to the development of numerous new iron-catalyzed reactions in the future.