Gamma radiation formation of sterculia gum-alginate-carbopol hydrogel dressing by grafting method for use in brain drug delivery

As the brain injury causes persistent neurological disorders that lead to the loss of neuron functions. The blood-brain-barrier limits the bioavailability of drugs required in therapeutic level. Hydrogel dressing can provide the localized drug release to the injured brain tissues that can reduce the limitations of the other drug delivery formulations. In the present article, sterculia gum and alginate polysaccharides were explored to form hydrogel dressing by radiation method for use in brain drug delivery. These dressings were characterized by AFM, XRD, FTIR, and C-13 NMR. The content of the artificial cerebrospinal fluids absorbed by sterculia-alginate dressing was 19.60 +/- 0.35 g. The release of citicoline drug, a nerve regenerative agent, occurred in controlled manner through Fickian mechanism and followed first order kinetic model. The porous dressings were permeable to O-2 and H2O and were biocompatible and antioxidant. Since the hydrogel dressings were prepared by radiation method so the resultant material was pure and sterile and could be explored for its application in brain drug delivery during brain injury.

Automated summary

Sterculia gum and alginate polysaccharides were explored to form hydrogel dressing by radiation method for brain drug delivery. The dressings showed controlled release of citicoline drug, good permeability, biocompatibility, and antioxidant properties. The pure and sterile material could potentially be used in brain drug delivery during brain injury.