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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency
Fabio Pacchiano et al.
CHEMICAL COMMUNICATIONS (2010)
The Coumarin-Binding Site in Carbonic Anhydrase Accommodates Structurally Diverse Inhibitors: The Antiepileptic Lacosamide As an Example and Lead Molecule for Novel Classes of Carbonic Anhydrase Inhibitors
Claudia Temperini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Polyamines Inhibit Carbonic Anhydrases by Anchoring to the Zinc-Coordinated Water Molecule
Fabrizio Carta et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins
Alfonso Maresca et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia
Vamsidhar Akurathi et al.
NUCLEAR MEDICINE AND BIOLOGY (2010)
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms IX and XII with boronic acids
Jean-Yves Winuma et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates
Alessio Innocenti et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Carbonic anhydrase inhibitors. Inhibition of the fungal β-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids
Alessio Innocenti et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian α-carbonic anhydrase isoforms
Seppo Parkkila et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Carbonic anhydrase inhibitors: Two-prong versus mono-prong inhibitors of isoforms I, II, IX, and XII exemplified by photochromic cis-1,2-α-dithienylethene derivatives
Daniel Vomasta et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Novel organometallic cationic ruthenium(II) pentamethylcyclopentadienyl benzenesulfonamide complexes targeted to inhibit carbonic anhydrase
Bradley T. Loughrey et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2009)
Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors
Alfonso Maresca et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX
Vincenzo Alterio et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Inhibition of carbonic anhydrase II by thioxolone: A mechanistic and structural study
Albert A. Barrese et al.
BIOCHEMISTRY (2008)
In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II
Esra Bayram et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Carbonic anhydrase inhibitors: Inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid
Alessio Innocenti et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Carbonic anhydrase inhibitors: Thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?
Alessio Innocenti et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols
Alessio Innocenti et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Carbonic anhydrase inhibitors: Interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV)
Alessio Innocenti et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Carbonic anhydrase inhibitors:: The very weak inhibitors dithiothreitol, β-mercaptoethanol, tris(carboxyethyl) phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX
Alessio Innocenti et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II and IX with some 1,3,4-oxadiazole- and 1,2,4-triazole-thiols
Gabriela Laura Almajan et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2008)
Dual Inhibitors of Matrix Metalloproteinases and Carbonic Anhydrases: Iminodiacetyl-Based Hydroxamate-Benzenesulfonamide Conjugates
Sergio M. Marques et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
Claudiu T. Supuran
NATURE REVIEWS DRUG DISCOVERY (2008)
Design, synthesis, and docking studies of new 1,3,4-thiadiazole-2thione derivatives with carbonic anhydrase inhibitory activity
Mohammed K. Abdel-Hamid et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I
Claudia Temperini et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Carbonic anhydrase inhibitors: Inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties
M. Amelia Santos et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates
Elisa Nuti et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
N-Hydroxyurea -: A versatile zinc binding function in the design of metalloenzyme inhibitors
Claudia Temperini et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Carbonic anhydrase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozymes I and II with some 1,3,4-oxadiazole-thiols
Muhammad Zareef et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2006)
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols
GL Almajan et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates
JY Winum et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate
A Innocenti et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates
A Innocenti et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet
S Rusconi et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Protease inhibitors: Synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating succinyl hydroxamate and iminodiacetic acid hydroxamate moieties
MA Santos et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2003)
Hydroxyurea is a carbonic anhydrase inhibitor
A Scozzafava et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties
A Scozzafava et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II
D Duda et al.
BIOCHEMISTRY (2001)
Carbonic anhydrase inhibitors, interaction of boron derivatives with isozymes I and II: A new binding site for hydrophobic inhibitors at the entrance of the active site as shown by docking studies
C Chazalette et al.
JOURNAL OF ENZYME INHIBITION (2001)
Carbonic anhydrase inhibitors: Allylsulfonamide, styrene sulfonamide, N-allyl sulfonamides and some of their Si, Ge, and B derivatives
C Chazalette et al.
JOURNAL OF ENZYME INHIBITION (2001)
Mechanism of cyanamide hydration catalyzed by carbonic anhydrase II suggested by cryogenic X-ray diffraction
A Guerri et al.
BIOCHEMISTRY (2000)
Carbonic anhydrase and matrix metalloproteinase inhibitors:: Sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes
A Scozzafava et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Carbonic anhydrase inhibitors; Phosphoryl-sulfonamides - A new class of high affinity inhibitors of isozymes I and II
I Fenesan et al.
JOURNAL OF ENZYME INHIBITION (2000)
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