期刊
CHEMICAL ENGINEERING JOURNAL
卷 419, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.129520
关键词
Degradable photothermal agent; Bioactive glass; Injectable composite hydrogel; Promoting gene expression; Bone tissue engineering
资金
- National Key R&D Program of China [2018YFC1106300, 2017YFC1105000]
- National Natural Science Foundation of China [51672088, 32000933]
- Beijing Municipal Health Commission [BMHC-2019-9, BMHC-2018-4, PXM2020_026275_000002]
- Natural Science Foundation of Guangdong Province [2017A030313019, 2019A1515110480]
- GDHVPS 2016, Natural Science Foundation of Guangdong Province of China [2019A1515010365]
The study developed double crosslinking injectable composite hydrogels for the treatment of tumor-related irregular bone defects, which combine both tumor therapy and bone regeneration functions. The composite hydrogel exhibited excellent photothermal effects, inhibiting tumor growth in mice and promoting new bone formation.
To treat tumor-related irregular bone defects, the implanted biomaterials after surgery should combine the functions of both tumor therapy and bone regeneration. To address the requirement, double crosslinking injectable composite hydrogels based on Furan-Sodium Alginate/bis-maleimide-Polyethylene Glycol/Copper doped Bioactive Glass-ceramic Microspheres (SA/PEG-CuBGM) were prepared using Diels-Alder (DA) reaction and ionic crosslinking. The prepared composite hydrogel showed excellent photothermal effects and killed most tumor cells in vitro and inhibited tumor growth in mice at the early implantation stage. The photothermal effects were derived from the oxide formed by doping copper ions in bioactive glass, and the photothermal temperature could be controlled by the CuBGM concentration and power densities of near infrared (NIR). Next, the photothermal agent concentration decreased rapidly with the degradation of the material. Additionally, the Ca, Si and Cu released from CuBGM improved the capability to stimulate the osteogenic differentiation of mBMSCs by upregulating bone-related gene expression, significantly promoting new bone formation in a femoral defect model of rats. Therefore, as the sequential progress of photothermal treatment and osteogenesis promotion is realized, the SA/PEG-CuBGM composite hydrogel will demonstrate considerable potential to aid the development and application of implanted biomaterials to tumor-related bone defects.
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