期刊
CHEMICAL ENGINEERING JOURNAL
卷 420, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2020.127710
关键词
Near infrared light; Graphene; Mesoporous silica; Lipid bilayer; Drug-controlled release; Synergistic therapy
资金
- National Natural Science Foundation of China [21773050, 21929401]
- Natural Science Foundation of Heilongjiang Province for Distinguished Young Scholars [JC2018003]
- Fundamental research of Heilongjiang Province [2017-KYYWFMY-0671]
This study successfully constructed a nanodrug carrier with high loading rate via lipid self-assembly, enabling synergistic chemophotothermal therapy for efficient solid tumor removal in vivo. The excellent integration of mesoporous-silica-coated rGO and lipid bilayer demonstrated great potential for graphene-based nanomaterials in biomedical applications.
The development of biomimetic technology offers excellent opportunities for the construction of therapeutic platforms with enhanced biocompatibility and antitumor performance. In this study, lipid-bilayer-coated reduced graphene oxide (rGO) modified with mesoporous-silica nanosheets was constructed via facile lipid self-assembly for effective synergistic chemophotothermal therapy. These nanodrug carriers were suitable for a high loading rate (53.3%) of doxorubicin (DOX). In vitro, after cellular internalization of these nanosheets, upon near infrared light (NIR) irradiation, the rGO in the nanoarchitecture generated heat not only for hyperthermia treatment but also for triggering lipid bilayer phase transition and on-demand controlled DOX release for chemotherapy. As expected, systematic in vivo antitumor evaluations confirmed the efficient solid tumor removal without recurrence. Our results revealed the excellent integration of the mesoporous-silica-coated rGO and lipid bilayer, which enabled the construction of a platform with the merits of both materials within a single unit. Thus, our results also indicate the great potential for the applications of graphene-based nanomaterials in biomedicine.
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