期刊
CHEMICAL ENGINEERING JOURNAL
卷 414, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.128836
关键词
Gelatin methacrylate; Surfactin-reinforced; Diabetes; Wound healing; Macrophage polarization; Angiogenesis
资金
- National Key R&D Program of China [2017YFE0105300]
- Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University [CX201968]
- Innovation Capability Support Program of Shaanxi [2020TD-042]
- China Agriculture Research System [CARS-29-jg-3]
- Key Research and Development Plan of Shaanxi Province [2017ZDXLNY-0304, 2019ZDLNY01-02-02]
The newly developed hydrogel shows great potential in treating chronic wounds of diabetic patients by regulating macrophage polarization and promoting angiogenesis.
Chronic wound healing is a severe complication that threatens the life of diabetic patients because of the damaged skin microvasculature and prolonged inflammation at the wound site. Novel wound dressing materials with the outstanding wound repair specialty are highly needed. Herein, a new hydrogel was developed with attractive capabilities in stiffness, swelling, self-healing, and biocompatibility, for the treatment of chronic wound in diabetes. The hybrid hydrogel was achieved by firstly synthesizing gelatin methacrylate (GelMA), then microbial lipopeptide-surfactin (SF) together with the photoinitiator were added before being crosslinked with 60 s of UV (i.e., GelMA-SF hydrogels). With the increase of SF concentrations, the porosity and tensile modulus of GelMA-SF hydrogels decreased, while the ultimate stress and compression modulus significantly increased compared with GelMA hydrogels. The feasibility of GelMA-SF hydrogels was tested by treating skin wounds in type I diabetic rats without coverage in vivo. For the first time, the study introduced SF to the GelMA network and revealed the mechanisms of the GelMA-SF hydrogels to promote diabetic wound healing via regulating macrophage polarization and promoting angiogenesis. The dynamic multifunctional hydrogel materials show great promise in the regeneration of difform wounds, especially, in situations with impaired angiogenesis and persistent inflammatory responses.
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