期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 98, 期 4, 页码 655-673出版社
WILEY
DOI: 10.1111/cbdd.13919
关键词
Alzheimer's disease; coumarin; monoamine oxidase; structure-activity relationship
资金
- Amrita Vishwa Vidyapeetham University [K-PHAR-20-628]
In recent years, Monoamine oxidase (MAO) has become a target for treating neurodegenerative diseases such as anxiety, depression, Alzheimer's, and Parkinson's diseases. Coumarins, known for their ease of synthesis, high therapeutic potential, and reversibility in inhibiting MAOs, are considered potent scaffold among several classes of inhibitors. This review focuses on the research in this field from 2014 to 2020, with a major emphasis on the structure-activity relationship of coumarin derivatives.
In the last few years, Monoamine oxidase (MAO) have emerged as a target for the treatment of many neurodegenerative diseases including anxiety, depression, Alzheimer's, and Parkinson's diseases. The MAO inhibitors especially selective and reversible inhibitors of either of the isoenzymes (MAO-A & MAO-B) have been given more attention as both the form have different therapeutic properties and hence can be used for different neurological disorders. The lack of selective and reversible inhibitors available for both the enzymes and severity of the neuronal disorder in society have opened a new door to the researchers to carry out large and dedicated researches in this field. Among the several classes of the molecule as the inhibitors, coumarins hold a rank as a potent scaffold with its ease of synthesis, high therapeutic potential, and reversibility in inhibiting MAOs. The current review is an update of the research in the field that covers the works during the last six years (2014-2020) with a major focus on the SAR of the coumarin derivatives including synthetic, natural, and hybrids of coumarins with FDA-approved drugs.
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