Review on marine sponge alkaloid, aaptamine: A potential antibacterial and anticancer drug

In recent years, biological macromolecules have piqued the interest of researchers owing to their vast variety of biological uses. As a result, the marine sponge is a multicellular heterotrophic parazoan with chemicals for defence against predator assaults, biofouling and microbial diseases. These priceless molecules are known as secondary metabolites, and they are essential for survival in a highly competitive environment. So far, over 5,000 marine natural compounds have been extracted from marine sponges, making them an excellent option for drug formulation. One among them is, aaptamine, a marine alkaloid with a benzo[de][1,6]-napthyridine framework extensively distributed in marine sponges. Due to this reason, aaptamine has been intensively researched for various biological purposes, including cancer and protease inhibition, offering fresh insights into novel treatments. Keeping this in mind, we reviewed the biological significance of the marine sponge alkaloid aaptamine.

Automated summary

In recent years, researchers have been interested in biological macromolecules due to their various biological uses. Marine sponges, as multicellular heterotrophic organisms, produce secondary metabolites for defense against predators, biofouling, and microbial diseases. Extracted from marine sponges, over 5,000 marine natural compounds, including aaptamine, have been studied extensively and show promise for various biological purposes, such as cancer treatment and protease inhibition.