4.3 Article

Pyrrolactams from Marine Sponge Stylissa massa Collected from Myanmar and Their Anti-Vpr Activities

期刊

CHEMICAL & PHARMACEUTICAL BULLETIN
卷 69, 期 7, 页码 702-705

出版社

PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c21-00227

关键词

Stylissa massa; pyrrolactam; stylissaol A; TREx-HeLa-Viral protein R (Vpr)

资金

  1. Ministry of Education, Culture, Sports, Science and Technology, Japan (JSPS KAKENHI) [JP20H00490, JP20KK0173, JP19H04649, 19K23794, 20K07111]
  2. Grants-in-Aid for Scientific Research [19K23794, 20K07111] Funding Source: KAKEN

向作者/读者索取更多资源

A new brominated pyrrolactam stylissaol A (1) and four known analogues were isolated from a marine sponge collected in Myanmar. Among them, 2-bromoaldisine exhibited anti-Vpr activity against TREx-HeLa-Vpr cells with potency comparable to that of positive control damnacanthal.
A new brominated pyrrolactam stylissaol A (1) together with four known analogues, 2-bromoaldisine, aldisine, spongiacidin D, and Z-hymenialdisine, were isolated from the EtOAc extract of marine sponge Stylissa nutssa collected in Myanmar. The absolute configuration at C-10 of 1 was determined as R by the electronic circular dichroism (ECD) data. Among the isolated compounds, 2-bromoaldisine showed anti-Viral Protein R (Vpr) activity against TREx-HeLa-Vpr cells with an effective dose of 10 mu M and its potency was comparable to that of positive control damnacanthal.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据