期刊
CHEMCATCHEM
卷 13, 期 22, 页码 4841-4847出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.202101172
关键词
Dynamic chemistry; Metathesis; Catalysis; Carbene; Exchange
资金
- Swedish Research Council
A series of olefin metathesis catalysts bearing cyclic (alkyl)(amino)carbene (CAAC) ligands of varying size and steric demand have been synthesized and evaluated for their performance in ring-closing, self, and cross-metathesis reactions. These catalysts exhibit high stability and activity, making them potentially valuable in the screening of bioactive compounds.
A series of olefin metathesis catalysts bearing cyclic (alkyl)(amino)carbene (CAAC) ligands of varying size and steric demand has been synthesized and evaluated in ring-closing-, self-, and cross-metathesis reactions at room temperature. The catalysts were also probed for potential applications in dynamic covalent chemistry. The majority of the catalysts showed high stability, and remained active in the reaction mixtures for several days, including in methanol-based solutions. Higher temperatures could be used to control the reactivity towards sterically challenging substrates, enabling formation of tetrasubstituted olefins. The CAAC complexes exhibited remarkable functional group tolerance towards heteroaromatic and nucleophilic additives, making them potentially useful in the screening of biologically active compounds.
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