4.6 Article

Extended Frontal Networks for Visual and Auditory Working Memory

期刊

CEREBRAL CORTEX
卷 32, 期 4, 页码 855-869

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhab249

关键词

attention; fMRI; frontal cortex; functional connectivity; multisensory

资金

  1. National Institutes of Health [R01-EY022229, R21EY027703, F31-NS103306, F32-EY026796]
  2. National Science Foundation [DGE-1247312, BCS-1829394]
  3. Center of Excellence for Learning in Education Science and Technology, National Science Foundation Science of Learning Center [SMA-0835976]

向作者/读者索取更多资源

Working memory supports the persistent representation of transient sensory information and involves different visual and auditory networks. Specific regions in the frontal lobes show robust activation during visual and auditory working memory tasks, exhibiting sensory preferences and stronger activation during task engagement. Overall, the sensory-biased frontal regions segregate into visual and auditory networks with interdigitated anatomical connections.
Working memory (WM) supports the persistent representation of transient sensory information. Visual and auditory stimuli place different demands on WM and recruit different brain networks. Separate auditory- and visual-biased WM networks extend into the frontal lobes, but several challenges confront attempts to parcellate human frontal cortex, including fine-grained organization and between-subject variability. Here, we use differential intrinsic functional connectivity from 2 visual-biased and 2 auditory-biased frontal structures to identify additional candidate sensory-biased regions in frontal cortex. We then examine direct contrasts of task functional magnetic resonance imaging during visual versus auditory 2-back WM to validate those candidate regions. Three visual-biased and 5 auditory-biased regions are robustly activated bilaterally in the frontal lobes of individual subjects (N = 14, 7 women). These regions exhibit a sensory preference during passive exposure to task stimuli, and that preference is stronger during WM. Hierarchical clustering analysis of intrinsic connectivity among novel and previously identified bilateral sensory-biased regions confirms that they functionally segregate into visual and auditory networks, even though the networks are anatomically interdigitated. We also observe that the frontotemporal auditory WM network is highly selective and exhibits strong functional connectivity to structures serving non-WM functions, while the frontoparietal visual WM network hierarchically merges into the multiple-demand cognitive system.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据