期刊
CEREBRAL CORTEX
卷 31, 期 11, 页码 5151-5164出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhab149
关键词
connectome; gradients; MRI; multimodal; neuroimaging
资金
- Savoy Foundation for Epilepsy
- Richard and Ann Sievers award
- Canadian Open Neuroscience Platform (CONP)
- Canadian Institutes of Health Research (CIHR) - McGill University's Faculty of Medicine
- Fonds de la Recherche du Quebec-Sante (FRQ-S) - Healthy Brains for Healthy Lives
- CIHR
- European Research Council [WANDERINGMINDSERC646927]
- National Science and Engineering Research Council of Canada [Discovery-1304413]
- Canadian Institutes of Health Research [CIHR FDN-154298, PJT-174995]
- SickKids Foundation [NI17-039]
- BrainCanada
- Azrieli Center for Autism Research
- FRQ-S
- Tier-2 Canada Research Chairs program
- Wellcome Trust [203730/Z/16/Z]
- Wellcome Trust [203730/Z/16/Z] Funding Source: Wellcome Trust
The study identified three axes of structural connectivity in human temporal cortex with consistent microstructural underpinnings and contributions to large-scale brain network function.
The temporal lobe is implicated in higher cognitive processes and is one of the regions that underwent substantial reorganization during primate evolution. Its functions are instantiated, in part, by the complex layout of its structural connections. Here, we identified low-dimensional representations of structural connectivity variations in human temporal cortex and explored their microstructural underpinnings and associations to macroscale function. We identified three eigenmodes which described gradients in structural connectivity. These gradients reflected inter-regional variations in cortical microstructure derived from quantitative magnetic resonance imaging and postmortem histology. Gradient-informed models accurately predicted macroscale measures of temporal lobe function. Furthermore, the identified gradients aligned closely with established measures of functional reconfiguration and areal expansion between macaques and humans, highlighting their potential role in shaping temporal lobe function throughout primate evolution. Findings were replicated in several datasets. Our results provide robust evidence for three axes of structural connectivity in human temporal cortex with consistent microstructural underpinnings and contributions to large-scale brain network function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据