4.6 Article

Hippocampal Representations of Event Structure and Temporal Context during Episodic Temporal Order Memory

期刊

CEREBRAL CORTEX
卷 32, 期 7, 页码 1520-1534

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhab304

关键词

event structure; hippocampal subfields; method of loci; temporal context reinstatement; temporal order memory

资金

  1. NSFC
  2. Israel Science Foundation (ISF) [31861143040]
  3. National Science Foundation of China [31730038]
  4. 111 Project [B07008]
  5. Sino-German Collaborative Research Project Crossmodal Learning [NSFC 62061136001/DFG TRR169]
  6. Guangdong Pearl River Talents Plan Innovative and Entrepreneurial Team grant [2016ZT06S220]

向作者/读者索取更多资源

The hippocampus is important in representing spatial locations and sequences, but its role in memory for the temporal order of random items is not well understood. This study found that different subfields of the hippocampus contain representations of multiple features of sequence structure and can flexibly transform these representations to support accurate temporal order memory.
The hippocampus plays an important role in representing spatial locations and sequences and in transforming representations. How these representational structures and operations support memory for the temporal order of random items is still poorly understood. We addressed this question by leveraging the method of loci, a powerful mnemonic strategy for temporal order memory that particularly recruits hippocampus-dependent computations of spatial locations and associations. Applying representational similarity analysis to functional magnetic resonance imaging activation patterns revealed that hippocampal subfields contained representations of multiple features of sequence structure, including spatial locations, location distance, and sequence boundaries, as well as episodic-like temporal context. Critically, the hippocampal CA1 exhibited spatial transformation of representational patterns, showing lower pattern similarity for items in same locations than closely matched different locations during retrieval, whereas the CA23DG exhibited sequential transformation of representational patterns, showing lower pattern similarity for items in near locations than in far locations during encoding. These transformations enabled the encoding of multiple items in the same location and disambiguation of adjacent items. Our results suggest that the hippocampus can flexibly reconfigure multiplexed event structure representations to support accurate temporal order memory.

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