4.7 Article

Facile fabrication of hollow mesoporous bioactive glass spheres: From structural behaviour to in vitro biology evaluation

期刊

CERAMICS INTERNATIONAL
卷 47, 期 24, 页码 34836-34844

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2021.09.024

关键词

Sol-gel process; Mesoporous bioactive glass; Controllable drug release; Antibacterial activity; Cytotoxicity

资金

  1. National Natural Science Foundation of China [31900964]
  2. Zhejiang Provincial Natural Science Foundation of China [LY20E030004]
  3. Keyi College [KY2019002]

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Introducing HMBGs can enhance drug loading capacity of bone-implantable delivery systems for controlled release of antibiotics. In vitro experiments showed that HMBGs sustain storage and release of vancomycin hydrochloride, inhibiting bacterial growth and providing a biomimetic microenvironment for cell adhesion and proliferation.
Bone defects accompanied by infection or inflammation can significantly delay the healing process. To simultaneously achieve controlled release of local antibiotics for infection control and bone healing, bone-implantable delivery systems have been considered as a promising strategy. This study aims to improve drug loading capacity of bone-implantable delivery systems by introducing hollow structure mesoporous bioactive glass nanospheres (HMBGs) through a sol-gel process. Particularly, such core-shell bimodal-porous structured nanoparticles were prepared through a sacrificing template using cetyltrimethylammonium bromide (CTAB) as surfactant. It was found that varying the amount of CTAB during the synthesis process is a simple and effective approach for tuning the particle size, morphology, and structure of HMBGs. For in vitro drug release, HMBGs could sustain storage and release of vancomycin hydrochloride (VAN) via diffusion-controlled mechanism, thereby inhibiting the bacteria growth in the subsequent bacterial study. Moreover, HMBGs incorporated with VAN provided a biomimetic microenvironment favored by cell adhesion and proliferation. These findings support the compatibility of HMBG nanoparticles with antibiotics and their potential application in the treatment of infectious bone defects.

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