期刊
CELLULAR SIGNALLING
卷 84, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2021.110009
关键词
Protein superfamily; Dephosphorylation; Protein evolution; Eutherian evolution; Mammalia; Post-translational modification; Putative sequences; Functional annotation
类别
资金
- JC Bose Fellowship from Science and Engineering Research Board, India [SB/S2/JC-071/2015]
- Bioinformatics Centre Grant - Department of Biotechnology, India [BT/PR40187/BTIS/137/9/2021]
The age of genomics has provided us with valuable information and tools to study whole genomes, leading to genome-wide studies that uncover interesting evolutionary patterns and the crucial role of phosphorylation in various organisms.
The age of genomics has given us a wealth of information and the tools to study whole genomes. This, in turn, has facilitated genome-wide studies among organisms that were relatively less studied in the pre-genomic era or are non-model organisms. This paves the way to the discovery of interesting evolutionary patterns, which are brought to light by genome-wide surveys of protein superfamilies. Phosphorylation is a post-translational modification that is utilised across all clades of life, and acts as an important signalling switch, regulating several cellular processes. Tyrosine phosphatases, which are found predominantly in eukaryotes, act on phosphorylated tyrosine residues and sometimes on other substrates. Extending on our previous effort to look for tyrosine phosphatases in the human genome, we have looked for sequences of the cysteine-based tyrosine phosphatase superfamily in thirty mammalian genomes from all across Mammalia and validated the sequences with the presence of the signature catalytic motif. Domain architecture annotation, followed by in-depth analysis, revealed interesting taxon-specific patterns such as subtle differences between the protein families in marsupials and early mammals versus placental mammals. Finally, we discuss an interesting case of loss of the tyrosine phosphatase domain from a gene product in the course of eutherian evolution.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据