4.7 Review

Biochemical and mechanical signals in the lymphatic vasculature

期刊

CELLULAR AND MOLECULAR LIFE SCIENCES
卷 78, 期 16, 页码 5903-5923

出版社

SPRINGER BASEL AG
DOI: 10.1007/s00018-021-03886-8

关键词

Mechanotransduction; Shear stress; Lymphatic vascular development; Valve; Lymphatic endothelial cells; PROX1; FOXC2; GATA2; Wnt; YAP; TAZ

资金

  1. NIH/NHLBI [R01HL131652, R01HL133216]
  2. NIH/NIGMS COBRE [P20 GM103441]
  3. Oklahoma Center for Adult Stem Cell Research [4340]
  4. American Heart Association [19POST34380819]

向作者/读者索取更多资源

The lymphatic vasculature is crucial for maintaining interstitial fluid balance, regulating lipid assimilation, and inflammatory response. Defects in lymphatic vessels or valves can lead to fluid accumulation, metabolic disorders, and inflammation. Studies have identified molecules and mechanical signals that play key roles in the development and function of the lymphatic vasculature, providing insights for potential therapies.
Lymphatic vasculature is an integral part of the cardiovascular system where it maintains interstitial fluid balance. Additionally, lymphatic vasculature regulates lipid assimilation and inflammatory response. Lymphatic vasculature is composed of lymphatic capillaries, collecting lymphatic vessels and valves that function in synergy to absorb and transport fluid against gravitational and pressure gradients. Defects in lymphatic vessels or valves leads to fluid accumulation in tissues (lymphedema), chylous ascites, chylothorax, metabolic disorders and inflammation. The past three decades of research has identified numerous molecules that are necessary for the stepwise development of lymphatic vasculature. However, approaches to treat lymphatic disorders are still limited to massages and compression bandages. Hence, better understanding of the mechanisms that regulate lymphatic vascular development and function is urgently needed to develop efficient therapies. Recent research has linked mechanical signals such as shear stress and matrix stiffness with biochemical pathways that regulate lymphatic vessel growth, patterning and maturation and valve formation. The goal of this review article is to highlight these innovative developments and speculate on unanswered questions.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据