期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 78, 期 16, 页码 5881-5902出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-021-03882-y
关键词
Biomechanical factors; HSC; Mechanical forces; Mechanosensor; Cell-cell adhesions; Cilium; Cytoskeleton
资金
- Natural Science Foundation of China [81730008]
- Zhejiang Key R&D Program (Science and Technology Department) [2019C03016]
- Zhejiang Provincial Natural Science Foundation of China [LQ19H080006]
- National Key R&D Program of China, Stem Cell and Translation Research [2018YFA0109300]
- Zhejiang Province Science Foundation for Distinguished Young Scholars [LR19H080001]
- National Natural Science Foundation of China [81870080, 91949115]
Hematopoietic stem cells (HSCs) can perceive both soluble signals and biomechanical inputs, with mechanotransduction playing a critical role in regulating their functions. However, the underlying molecular details of biomechanical regulation in HSCs are still poorly understood.
Hematopoietic stem cells (HSCs) perceive both soluble signals and biomechanical inputs from their microenvironment and cells themselves. Emerging as critical regulators of the blood program, biomechanical cues such as extracellular matrix stiffness, fluid mechanical stress, confined adhesiveness, and cell-intrinsic forces modulate multiple capacities of HSCs through mechanotransduction. In recent years, research has furthered the scientific community's perception of mechano-based signaling networks in the regulation of several cellular processes. However, the underlying molecular details of the biomechanical regulatory paradigm in HSCs remain poorly elucidated and researchers are still lacking in the ability to produce bona fide HSCs ex vivo for clinical use. This review presents an overview of the mechanical control of both embryonic and adult HSCs, discusses some recent insights into the mechanisms of mechanosensing and mechanotransduction, and highlights the application of mechanical cues aiming at HSC expansion or differentiation.
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