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Cross-reactive antibody immunity against SARS-CoV-2 in children and adults

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Kevin J. Selva et al.

Summary: The study reveals that elderly individuals have higher levels of cross-reactive antibodies before the COVID-19 pandemic, while children have fewer exposures to coronaviruses before the emergence of the virus, resulting in less-experienced but stronger humoral immunity. Age-dependent analysis in COVID-19 patients shows elevated class-switched antibodies in the elderly and stronger Fc responses in children.

NATURE COMMUNICATIONS (2021)

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Article Immunology

Cross-reactive antibody against human coronavirus OC43 spike protein correlates with disease severity in COVID-19 patients: a retrospective study

Li Guo et al.

Summary: This study revealed that there is a cross-reactivity between antibodies against seasonal human coronaviruses and SARS-CoV-2 in COVID-19 patients. Specifically, higher levels of HCoV-OC43 antibodies were found to be associated with disease severity in COVID-19 patients.

EMERGING MICROBES & INFECTIONS (2021)

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Article Multidisciplinary Sciences