Dynamics of the SARS-CoV-2 antibody response up to 10 months after infection

Letter Immunology

Changes in the humoral immunity response in SARS-CoV-2 convalescent patients over 8 months

Pai Peng et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Evolution of antibody immunity to SARS-CoV-2

Christian Gaebler et al.

Summary: After infection with SARS-CoV-2, antibody levels against the spike protein decrease significantly, but the number of memory B cells remain unchanged, indicating an evolving humoral response at 6.2 months after infection.

NATURE (2021)

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Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

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Article Microbiology

Persistence of Anti-SARS-CoV-2 Antibodies Depends on the Analytical Kit: A Report for Up to 10 Months after Infection

Julien Favresse et al.

Summary: This study investigated the temporal dynamic changes of immune response after SARS-CoV-2 infection in hospitalized and non-hospitalized symptomatic patients over a 10-month period. Six different analytical kits were used to detect SARS-CoV-2 antibodies, showing a high inter-methodology variability. Total antibody assays had higher positivity rates and reached peak positivity rates sooner compared to IgG assays, with better inter-assay agreement between them. Stratification by disease severity revealed a much-elevated serological response in hospitalized patients. The waning effect of serological response reported in some studies may depend on the assay used.

MICROORGANISMS (2021)

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Article Microbiology

Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans

Kanika Vanshylla et al.

Summary: The study reveals a wide spectrum of neutralizing antibody response to SARS-CoV-2, with sustained antibodies in the majority of individuals with mild COVID-19 for up to 10 months after infection.

CELL HOST & MICROBE (2021)

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Article Medicine, General & Internal

Seroprevalence and humoral immune durability of anti-SARS-CoV-2 antibodies in Wuhan, China: a longitudinal, population-level, cross-sectional study

Zhenyu He et al.

LANCET (2021)

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Article Immunology

Comprehensive analysis of SARS-CoV-2 antibody dynamics in New Zealand

Alana L. Whitcombe et al.

Summary: This study found that antibodies to SARS-CoV-2 can persist for up to 8 months following mild-to-moderate infection, with RBD and S protein IgG, as well as NAbs, being relatively stable over time. The robust antibody response observed may be attributed to the initial exposure without immune boosting due to lack of community transmission in New Zealand.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2021)

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Editorial Material Medicine, General & Internal