期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 18, 期 10, 页码 2325-2333出版社
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/s41423-021-00750-4
关键词
CD8(+) T cell; Activation; T-cell exhaustion; SARS-CoV-2; COVID-19
类别
资金
- 2020 Joint Research Project of the Institutes of Science and Technology
CD8(+) T cells play a protective role in the immune response against COVID-19, exhibiting activated phenotypes in patients despite a decrease in absolute numbers. The upregulation of inhibitory immune checkpoint receptors and expression of exhaustion-associated gene signatures in these cells have been reported, but the true exhaustion of CD8(+) T cells during COVID-19 remains controversial.
In addition to CD4(+) T cells and neutralizing antibodies, CD8(+) T cells contribute to protective immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In patients with COVID-19, CD8(+) T cells exhibiting activated phenotypes are commonly observed, although the absolute number of CD8(+) T cells is decreased. In addition, several studies have reported an upregulation of inhibitory immune checkpoint receptors, such as PD-1, and the expression of exhaustion-associated gene signatures in CD8(+) T cells from patients with COVID-19. However, whether CD8(+) T cells are truly exhausted during COVID-19 has been a controversial issue. In the present review, we summarize the current understanding of CD8(+) T-cell exhaustion and describe the available knowledge on the phenotypes and functions of CD8(+) T cells in the context of activation and exhaustion. We also summarize recent reports regarding phenotypical and functional analyses of SARS-CoV-2-specific CD8(+) T cells and discuss long-term SARS-CoV-2-specific CD8(+) T-cell memory.
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