Sweet Dre-ams about intersectional genetics

Specific cell targeting with one site-specific recombinase is challenging. In this issue of Cell Stem Cell, Han et al. (2021) released a collection of Dre drivers and demonstrate how two recombinases can be combined to improve the cell specificity of lineage tracing and gene inactivation in mice.

Automated summary

The study demonstrates how combining two recombinases can improve cell specificity in mice, enhancing lineage tracing and gene inactivation.