期刊
CELL STEM CELL
卷 28, 期 8, 页码 1343-1361出版社
CELL PRESS
DOI: 10.1016/j.stem.2021.05.012
关键词
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资金
- NIH [R35CA210088, 5U01DK103155-04]
- JSPS
- Takeda Science Foundation visionary research grant
- Uehara Memorial Foundation
- Naito Foundation
- Daiwa-Shoken Health Foundation
- Waksman Foundation of Japan
- Koyanagi Foundation
- Research Foundation for Pharmaceutical Sciences
- Yakult Bio-Science Foundation
- Tokyo Biochemical Research Foundation
- NOVARTIS Foundation (Japan) for the Promotion of Science
- SGH Foundation
- Daiichi Sankyo Foundation of Life Science
- AMED (PRIME)
- AMED (P-CREATE)
- Herbert Irving Comprehensive Cancer Center
- Inoue science research award
- [DK100342]
- [DK113144]
- [DK120650]
- [R01DK114436]
- [R01AA026297]
- [P01CA 098101]
- [U54CA163004]
- [2P30CA013696]
In this article, we discuss the biology of gastroesophageal stem cells and their role as cells of origin in cancer. The interactions between the stromal niche and gastroesophageal stem cells play a vital role in metaplasia and early expansion of mutated stem-cell-derived clones during carcinogenesis. New approaches are being developed to better study gastroesophageal stem cells and advance the field.
The esophagus and stomach, joined by a unique transitional zone, contain actively dividing epithelial stem cells required for organ homeostasis. Upon prolonged inflammation, epithelial cells in both organs can undergo a cell fate switch leading to intestinal metaplasia, predisposing to malignancy. Here we discuss the biology of gastroesophageal stem cells and their role as cells of origin in cancer. We summarize the interactions between the stromal niche and gastroesophageal stem cells in metaplasia and early expansion of mutated stem-cell-derived clones during carcinogenesis. Finally, we review new approaches under development to better study gastroesophageal stem cells and advance the field.
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