The study found that tumor-infiltrating myeloid cells have a higher glucose uptake capacity than tumor cells, while tumor cells exhibit enhanced glutamine metabolism, suggesting that nutrient partitioning in the tumor microenvironment may be more complex than previously thought.
Tumor cells utilize glucose to engage in aerobic glycolysis, fulfilling their metabolic demands for extensive proliferation. A recent study in Nature discovers that tumor-infiltrating myeloid cells exhibit a superior glucose uptake capacity over tumor cells, which present enhanced glutamine metabolism, suggesting that nutrient partitioning in the TME might be more complex than previously thought.
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